Title

Salivary pH and buffering capacity among gastroesophageal reflux disease patients with dental erosion

Authors

Nilima Jain^1,*, Mansi Atri², Hiren Hansraj Patadiya³, Debashis Roy⁴, Shalini Rastogi⁵ & Rachna Rohatgi⁶

Affiliation

¹Department of Oral Medicine and Radiology, Teerthanker Mahaveer Dental College & Research Centre, Moradabad, India; ²Department of Public Health Dentistry, Esic Dental College and Hospital, Delhi, India; ³Dental practitioner, My Dental Southbridge, USA; ⁴Department of Public Health Dentistry, Mithila Minority Dental College & Hospital, Darbhanga, India; ⁵Department of Physiology, School of Medical Sciences & Research, Sharda University, Greater Noida, India; ⁶Department of Anatomy, School of Medical Sciences and Research, Sharda University Greater Noida, India; *Corresponding author

Email

Nilima Jain - E-mail: annejain001@gmail.com
Mansi Atri - E-mail: drmansiatri@gmail.com
Hiren Hansraj Patadiya - E-mail: drhirendmd@gmail.com
Debashis Roy - E-mail: drdebashisroy92@gmail.com
Shalini Rastogi - E-mail: shalini.rastogi@sharda.ac.in
Rachna Rohatgi - E-mail: rachna.rohtagi@sharda.ac.in

Article Type

Research Article

Date

Received May 1, 2026; Revised May 31, 2026; Accepted May 31, 2026, Published May 31, 2026

Abstract

Gastroesophageal reflux disease creates a persistently acidic oral environment that compromises salivary protective mechanisms and promotes dental erosion. Therefore, it is of interest to evaluate salivary pH and buffering capacity in patients with gastroesophageal reflux disease and their association with dental erosion compared to healthy controls. Hence, a total of 120 participants (60 GERD patients and 60 controls) underwent salivary analysis and clinical assessment using the Basic Erosive Wear Examination index. GERD patients demonstrated significantly lower salivary pH and buffering capacity along with higher prevalence and severity of dental erosion (p<0.001). Impaired salivary protective factors in GERD patients highlight the importance of early diagnosis and preventive strategies to reduce erosion risk.

Keywords

Salivary PH, buffering capacity, gastroesophageal reflux disease (GERD), dental erosion, Basic Erosive Wear Examination (BEWE) index

Citation

Jain et al. Bioinformation 22(5): 2799-2805 (2026)

Edited by

Hiroj Bagde

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.