Title

Assessment of regenerative endodontic procedures using platelet-rich fibrin in immature necrotic teeth

Authors

Setu Kalaria^1,*, T.Rajsundar², Pradnya Jadhav³, B.M Divya⁴, Abdullah Tamboli⁵ & Kushal Gajendra Shinde⁶

Affiliation

¹Department of Conservative Dentistry and Endodontics, AMC Dental College, Khokhra, Ahmedabad, India; ²Department of periodontology, Tamil Nadu government dental college and hospital, Satellite peripheral unit, Tambaram, India; ³Department of Public Health Dentistry, Government Dental College and Hospital, Chhatrapati Sambhajinagar, India; ⁴Department of Public Health Dentistry, DAPM RV Dental College, Bangalore, India; ⁵Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth (Deemed to be university) Dental college and hospital, Sangli, India; ⁶Department of Public health dentistry, CSMSS Dental College, Chhatrapati Sambhajinagar, India; *Corresponding author

Email

Setu Kalaria - E-mail: seturveshk1121@gmail.com
T. Rajsundar - E-mail: rajaj_sundar@yahoo.co.in
Pradnya Jadhav - E-mail: drpradnya789@gmail.com
BM Divya - E-mail: docdivya24@gmail.com
Abdullah Tamboli - E-mail: abdullahomfs@gmail.com
Kushal Gajendra Shinde - E-mail: dr.kushalshinde@gmail.com

Article Type

Research Article

Date

Received May 1, 2026; Revised May 31, 2026; Accepted May 31, 2026, Published May 31, 2026

Abstract

Management of immature permanent teeth with pulp necrosis remains a clinical challenge due to incomplete root development and limitations of conventional endodontic approaches. Therefore, it is of interest to evaluate the clinical and radiographic efficacy of regenerative endodontic procedures using platelet-rich fibrin compared with mineral trioxide aggregate apexification in 40 immature necrotic teeth. Patients were randomly allocated into two groups and assessed clinically and radiographically using periapical radiographs and CBCT at 3, 6 and 12 months. The platelet-rich fibrin group demonstrated significantly greater improvement in root length, dentinal wall thickness and apical closure compared to the apexification group, with higher clinical success rates. Regenerative endodontic procedures using platelet-rich fibrin appear to be more effective in promoting root maturation and periapical healing in immature necrotic teeth.

Keywords

Regenerative endodontics; platelet-rich fibrin (PRF); immature necrotic teeth; root maturation; apexification; periapical healing

Citation

Kalaria et al. Bioinformation 22(5): 2811-2816 (2026)

Edited by

Hiroj Bagde

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.