Title

Effect of pre-treatment systemic antibiotics on post-operative pain following single-visit root canal therapy in vital mandibular first premolars: A randomized controlled trial

Authors

Shefali Talekar¹, Shivam Arora², Amit Patil¹, Sumita Bhagwat³, Ankita Khose³ & Sanpreet Singh Sachdev^4,*

Affiliation

¹Department of Conservative Dentistry and Endodontics, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Belapur CBD, Navi Mumbai, Maharashtra, India; ²Department of Radiodiagnosis, MGM Medical College and Hospital, Vashi, Navi Mumbai, Maharashtra, India; ³Department of Conservative Dentistry and Endodontics, DY Patil University School ofDentistry, Nerul, Navi Mumbai, Maharashtra, India; ⁴Department of Oral Pathology and Microbiology, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Belapur CBD, Navi Mumbai, Maharashtra, India; *Corresponding author

Email

Shefali Talekar - E-mail: shefali.talekar@bharatividyapeeth.edu

Shivam Arora - E-mail: shivam8888@gmail.com

Amit Patil - E-mail: amit.patil@bharatividyapeeth.edu

Sumita Bhagwat - E-mail: sumita.bhagwat@dypatil.edu

Ankita Khose - E-mail: ankita.khose@dypatil.edu

Sanpreet Singh Sachdev - E-mail: sanpreet.singh@bharatividyapeeth.edu

Article Type

Research Article

Date

Received May 1, 2026; Revised May 31, 2026; Accepted May 31, 2026, Published May 31, 2026

Abstract

Most post-endodontic pain can be effectively managed pharmacologically without antibiotic use. However, some clinicians continue to prescribe antibiotics prophylactically, driven by concern over flare-ups or patient expectations. Therefore, it is of interest to evaluate the effect of pre-treatment systemic antibiotic prophylaxis on post-operative pain following single-visit root canal therapy. A randomized controlled trial was conducted involving 60 systemically healthy patients requiring root canal treatment in vital mandibular first premolars. Participants were divided into two groups: Group A received a single pre-operative dose of 500 mg amoxicillin one hour prior to treatment, while Group B received no antibiotic. Subjects who received antibiotics reported significantly lower pain scores during the initial 24 hours compared to the non-antibiotic group (p < 0.05). Thus, pre-operative systemic antibiotics may provide early post-operative pain relief in vital teeth, but antibiotic use should be judicious and reserved for specific clinical indications.

Keywords

Amoxicillin; endodontic pain; single-visit endodontics; analgesic effect; antibiotic prophylaxis; randomized controlled trial

Citation

Talekar et al. Bioinformation 22(5): 2910-2915 (2026)

Edited by

Rashmi Laddha

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.