Title

Clinical efficiency of mesenchymal stem cells for bone regeneration and osseointegration

Authors

Ghazala Khurshid¹, Reddy Chaithanya^2,*, Akshyata Panda³, Khushboo Changani⁴, Shailesh Menat⁴ & Haren Pandya⁵

Affiliation

¹Department of Prosthodontics and Crown & Bridge, Consultant at Lake View Hospital, Ranchi, Jharkhand, India; ²Department of Prosthodontics, Government Dental College and Hospital, Kadapa andhra Pradesh, India; ³Department of Periodontics and Oral Implantology, Institute of Dental Sciences, Siksha O Anusandhan University, Bhubaneswar, India; ⁴Department of Oral and Maxillofacial Surgery, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India; ⁵Department of Oral Surgery, DDU, NADIAD, Gujarat, India; *Corresponding author

Email

Ghazala Khurshid - E-mail: drghazala1395@gmail.com
Reddy Chaithanya - E-mail: cdhanya777@gmail.com
Akshyata Panda - E-mail: akshyatapanda@soa.ac.in
Khushboo Changani - E-mail: drkhushichangani@gmail.com
Shailesh Menat - E-mail: drshail_menat@yahoo.com
Haren Pandya - E-mail: drharenpandya@gmail.com

Article Type

Research Article

Date

Received May 1, 2026; Revised May 31, 2026; Accepted May 31, 2026, Published May 31, 2026

Abstract

Achieving predictable bone regeneration and optimal osseointegration remains a clinical challenge in dental implant therapy, particularly in sites with compromised bone quality. Therefore, it is of interest to evaluate the clinical efficiency of mesenchymal stem cells (MSCs) in enhancing bone regeneration and improving osseointegration in patients receiving dental implants. Hence, sixty patients were randomly divided into two groups: Group A received MSCs combined with bone grafts, while Group B received conventional bone grafts alone. Over a six-month follow-up period, Group A demonstrated significantly higher implant stability quotient (ISQ) values, greater bone volume gain and increased bone density compared to Group B. Implant survival was 100% in the MSC group, whereas the control group showed a survival rate of 96.7%. Thus, we show that the adjunctive use of mesenchymal stem cells can improve clinical outcomes in oral implantology.

Keywords

Mesenchymal Stem Cells (MSCs), bone regeneration, osseointegration, dental implants, bone grafting, implant stability, cone beam computer tomography (CBCT), tissue engineering, and regenerative dentistry

Citation

Khurshid et al. Bioinformation 22(5): 2949 -2952 (2026)

Edited by

Rashmi Laddha

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.