Title

Comparative evaluation of oral versus intravenous antibiotic prophylaxis prior to obstetric and gynecological procedures

Authors

Pradeep Rathore¹, Ashis Tiwari² & Shambhavi Soni^3,*

Affiliation

¹Department of General Surgery, Government Medical College, Datia, Madhya Pradesh, India; ²Department of General Medicine, Government Medical College, Datia, Madhya Pradesh, India; ³Department of Obstetrics and Gynaecology, Government Medical College, Datia, Madhya Pradesh, India; *Corresponding author

Email

Pradeep Rathore - E-mail: Prathore663@gmail.com; Phone: +91 8463044344
Ashis Tiwari - E-mail: ashishtiwari.gwldr@gmail.com; Phone: +91 6263218871
Shambhavi Soni - E-mail: drshambhavisoni@gmail.com; Phone: +91 9088088252

Article Type

Research Article

Date

Received May 1, 2026; Revised May 31, 2026; Accepted May 31, 2026, Published May 31, 2026

Abstract

Surgical site infections (SSI) remain among the most common post-operative complications following gynecological and obstetric surgeries. Pre-operative antibiotic prophylaxis plays a key role in preventing SSIs, with intravenous administration serving as the conventional standard. Recent interest has turned toward oral antibiotic prophylaxis as a more convenient and cost-effective alternative. Hence, this prospective comparative study included 221 women undergoing elective gynecological or obstetric procedures, randomly assigned to receive either oral antibiotics (Group A) or intravenous antibiotics (Group B) prior to surgery. Post-operative outcomes, including surgical site infection, febrile morbidity, urinary tract infection duration and hospital stay, were evaluated. Thus, we show the equivalent efficacy between oral and intravenous prophylaxis in infection prevention, advancing clinical practice by supporting oral antibiotic use as a safe, practical and economical alternative in suitable surgical cases.

Keywords

Antibiotic prophylaxis, obstetric surgery, gynecological surgery, surgical site infection (SSI), oral antibiotics, intravenous antibiotics

Citation

Rathore et al. Bioinformation 22(5): 3101-3104 (2026)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.