Title

Troponin I as a prognostic marker for outcomes in septic patients admitted to the ICU: Evidence from a government medical college of Madhya Pradesh, India

Authors

Vikas Rangare¹, Jyoti Nagwanshi¹, Abhay Kumar² & Kapil Raghuwanshi^3,*

Affiliation

¹Department of Medicine, Chhindwara Institute of Medical Sciences, Chhindwara, Madhya Pradesh, India; ²Department of ENT, Chhindwara Institute of Medical Sciences, Chhindwara, Madhya Pradesh, India; ³Department of Biochemistry, Chhindwara Institute of Medical Sciences, Chhindwara, Madhya Pradesh, India; *Corresponding author

Email

Vikas Rangare - E - mail: vikasrangare80@gmail.com
Jyoti Nagwanshi - E - mail: jyoti.nagwanshi13@gmail.com
Abhay Kumar - E - mail: abhaykr20@yahoo.co.in
Kapil Raghuwanshi - E - mail: drkapilraghuwanshi28@gmail.com

Article Type

Research Article

Date

Received May 1, 2026; Revised May 31, 2026; Accepted May 31, 2026, Published May 31, 2026

Abstract

Sepsis remains a leading cause of morbidity and mortality among critically ill patients, with early identification of high-risk individuals being vital for improving outcomes. Cardiac troponin I, a biomarker of myocardial injury, is often elevated in sepsis and may serve as an indicator of systemic inflammation and cardiovascular stress. Hence, this prospective observational study conducted from December 2024 to January 2026 at District Hospital Chhindwara, India, included 170 adult sepsis patients admitted to the ICU. Troponin I levels within 24 hours of admission were measured and analyzed against clinical variables including SOFA score; mechanical ventilation, vasopressor use and length of ICU stay. Elevated troponin was detected in 67.6% of patients and was significantly associated with higher mortality (38.3% vs. 9.1%, p < 0.001) and greater need for organ support; logistic regression confirmed troponin as an independent mortality predictor (adjusted OR = 5.12, 95% CI 1.65–15.9, p = 0.004). Thus, we show troponin I as a valuable prognostic marker in sepsis, supporting its early measurement for risk stratification and targeted management.

Keywords

Sepsis, Troponin I, ICU mortality, septic cardiomyopathy, sequential organ failure assessment (SOFA) score, biomarkers, critical care

Citation

Rangare et al. Bioinformation 22(5): 3125-3130 (2026)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.