Title

Comparative evaluation of salivary oxidative stress markers in oral leukoplakia and oral submucous fibrosis: A cross-sectional study

Authors

Ashni Chatterjee¹, Sowjanya Gunukula², Mousami Kundu³, Priya Sinha^4,*, Sameer Gupta⁵ & Gaurav Sharma⁶

Affiliation

¹Department of Oral Medicine and Radiology, Geetanjali Dental and Research Institute, Udaipur, Rajasthan, India; ²Department of General Dentistry, Flomo Dental, Private Clinic, Independent Researcher, 295 Ukiah St, Lewisville TX 75056; ³Department of Oral & Maxillofacial Surgery, Awadh Dental College and Hospital, Jamshedpur, Jharkhand, India; ⁴Department of Oral Medicine and Radiology, Geetanjali Dental and Research Institute, Udaipur, Rajasthan, India; ⁵Department of Oral & Maxillofacial Surgery, Inderprastha Dental College and Hospital, Sahibabad, Ghaziabad, Uttar Pradesh, India; ⁶Department of Dentistry, SGT Dental College and Research Institute, Budhera, Gurgaon, Haryana, India; *Corresponding author

Email

Ashni Chatterjee - E-mail: ashni.chatterjee29@gmail.com

Sowjanya Gunukula - E-mail: drgunukula.dds@gmail.com

Mousami Kundu - E-mail: drmousamimds@gmail.com

Priya Sinha - E-mail: dr.priyasinha02@gmail.com

Sameer Gupta - E-mail: sameer.gupta83@yahoo.in

Gaurav Sharma - E-mail: gauravsharma.121291@gmail.com

Article Type

Research Article

Date

Received June 1, 2026; Revised June 30, 2026; Accepted June 30, 2026, Published June 30, 2026

Abstract

Oral leukoplakia and oral submucous fibrosis (OSMF) are potentially malignant disorders with a significant risk of progressing to oral cancer. Oxidative stress is a key factor in their development, causing cellular damage and disease progression. Therefore, it is of interest to evaluate and compare salivary oxidative stress markers in patients with these conditions. Data shows high levels of oxidative stress and lower antioxidant levels in both conditions compared to healthy controls, with OSMF showing severe imbalance. Thus, we show salivary oxidative stress markers as potential non-invasive diagnostic tools for early detection and monitoring of oral potentially malignant disorders.

Keywords

Oral leukoplakia, oral submucous fibrosis (OSMF), oxidative stress, salivary biomarkers, malondialdehyde

Citation

Chatterjee et al. Bioinformation 22(6): 3294-3299 (2026)

Edited by

Ritik Kashwani

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.