Title
Comparative evaluation of ease in dental treatment using midazolam versus midazolam-ketamine in uncooperative children
Authors
Vaishali Sharma1, Shalu Majreti2, Naina Agarwal3, Yihan Fu4, Indushree Saini5, P.S Prakhyath6,*, Kapil Paiwal7 & Manish Jain8
Affiliation
1Department of Paediatrics, Government Medical College, Amritsar, Punjab, India; 2Department of Dentistry, Government Medical College and Hospital, Haldwani, Uttarakhand, India; 3Department of Pedodontics, BBD College of Dental Sciences, Lucknow, Uttar Pradesh, India; 4Department of Dentistry, Smilebuilderz, Lancaster, Pennsylvania, United States; 5Department of Oral Medicine and Radiology, Jaipur Dental College and Hospital, Maharaja Vinayak Global University, Jaipur, Rajasthan, India; 6Department of Prosthodontics, Crown and Bridge, A J Institute of Dental Sciences, Mangalore, Karnataka, India; 7Department of Oral Pathology and Microbiology, Daswani Dental College and Hospital, Kota, Rajasthan, India; 8Department of Dentistry, RVRS Government Medical College and MG Hospital, Bhilwara, Rajasthan, India; *Corresponding author
Vaishali Sharma - E-mail: vaishalime92@gmail.com
Shalu Majreti - E-mail: majretishalu22@gmail.com
Naina Agarwal - E-mail: drnainavs@gmail.com
Yihan Fu - E-mail: annfu2010@gmail.com
Indushree Saini - E-mail: dr.indufortishealthcare@gmail.com
P.S Prakhyath - E-mail: prakhyath.p.s@gmail.com
Kapil Paiwal - E-mail: drpaiwal@gmail.com
Manish Jain - E-mail: mahaveerhospital23@gmail.com
Article Type
Research Article
Date
Received June 1, 2026; Revised June 30, 2026; Accepted June 30, 2026, Published June 30, 2026
Abstract
Effective sedation strategies for non-cooperative children in dental care remain a significant clinical challenge. Therefore, it is of interest to compare the effectiveness of midazolam alone versus midazolam combined with ketamine in managing uncooperative pediatric dental patients. Hence, seventy children were equally divided into two groups, with assessment of behavioral response, treatment compliance and operator comfort. The combination regimen demonstrated improved sedation quality, better compliance and enhanced operator comfort compared to midazolam alone. Thus, we show combination sedation as a more effective approach for pediatric dental management, optimizing clinical outcomes and procedural efficiency.
Keywords
Midazolam, ketamine, pediatric dentistry, conscious sedation, behavior management, uncooperative children
Citation
Sharma et al. Bioinformation 22(6): 3305-3309 (2026)
Edited by
Vini Mehta
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
