Title
DFDBA with or without allogenic human dental pulp derived mesenchymal stem cells in treatment of mandibular class II furcation defects
Authors
Kousain Sehar*, Abhima Kumar, Sabiha Parwaiz, Shrey Shaileshbhai Patel, Mohd Irfan & M
Kamalnathgandhi
Affiliation
Department of Periodontology and Oral Implantology, Indira Gandhi Government Dental College & Hospital, Jammu, Jammu and Kashmir, India, 180005; *Corresponding author
Kousain Sehar - E-mail: k.sehar276@yahoo.in
Abhima Kumar - E-mail: abhima007@yahoo.co.in
Sabiha Parwaiz - E-mail: sabihaparwaiz@gmail.com
Shrey Shaileshbhai Patel - E-mail: shreypatel37516@gmail.com
Mohd Irfan - E-mail: mohdirfanch9@gmail.com
M Kamalnathgandhi - E-mail: kamalnathgandhi@gmail.com
Article Type
Research Article
Date
Received June 1, 2026; Revised June 30, 2026; Accepted June 30, 2026, Published June 30, 2026
Abstract
It is a challenging task to regenerate the periodontium at the furcation defect. Tissue engineering techniques using stem cells have gained importance in medical field in recent years. Various methods are tried to treat furcation defects. Therefore, it is of interest to assess DFDBA with or without allogenic human dental pulp derived mesenchymal stem cells in treatment of mandibular class II furcation defects. Hence, 28 systemically healthy individuals with at least one mandibular class II furcation defect were divided into 2 groups. Group A (n=14) patients were treated with DFDBA alone and Group B (n= 14) were treated with combination of DFBDA and allogenic dental pulp derived mesenchymal stem cells. Clinical parameters i.e., vertical relative attachment level (V-RAL), vertical probing depth (VPD), horizontal probing depth (HPD) and gingival recession (GR) were recorded at baseline and 6-months post-operatively. DPSCs with DFDBA did not show any statistical significance in both clinical and hard tissue outcome parameters.
Keywords
Dental pulp stem cells (DPSCs), demineralized freeze-dried bone allograft (DFDBA), regeneration, tissue engineering
Citation
Sehar et al. Bioinformation 22(6): 3357-3361 (2026)
Edited by
P Babaji
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
