Title

0.1% octenidine versus 0.2% chlorhexidine mouthwashes for plaque-induced gingivitis: A triple-blinded randomized controlled trial

Authors

Sharvari Pokale¹, Sneh Agrawal^l, *, Prajakta Rao¹, Pranita Dalave¹, Vivek Sharma¹ & Sanpreet Singh Sachdev²

Affiliation

¹Department of Periodontology, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, India; ²Department of Periodontology, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, India; *Corresponding author

Email

Sharvari Pokale - E-mail: dr.sharvari13@gmail.com

Sneh Agrawal - E-mail: sneh.agrawal@bharatividyapeeth.edu

Prajakta Rao - E-mail: prajakta.rao@bharatividyapeeth.edu

Pranita Dalave - E-mail: drpranitadalave@gmail.com

Vivek Sharma - E-mail: drvivek.sharma33@gmail.com

Sanpreet Singh Sachdev - E-mail: sanpreet.singh@bharatividyapeeth.edu

Article Type

Research Article

Date

Received June 1, 2026; Revised June 30, 2026; Accepted June 30, 2026, Published June 30, 2026

Abstract

Plaque-induced gingivitis is commonly managed by mechanical plaque control, but adjunctive mouthrinses may improve outcomes. Therefore, it is of interest to compare 0.1% octenidine, 0.2% chlorhexidine and placebo in 66 patients with plaque-induced gingivitis treated with scaling and root planing. Gingival index, plaque index, stain index and colony-forming units were recorded at baseline, 7 days and 15 days. Both octenidine and chlorhexidine produced significant reductions in gingival inflammation, plaque and microbial load compared with placebo, while chlorhexidine caused significantly greater staining. Thus, 0.1% octenidine showed efficacy comparable to 0.2% chlorhexidine with better cosmetic acceptability, supporting its use as an alternative adjunct in plaque-induced gingivitis.

Keywords

Plaque-induced gingivitis, octenidine dihydrochloride, chlorhexidine digluconate, antimicrobial mouthrinse, gingival inflammation

Citation

Pokale et al. Bioinformation 22(6): 3405-3411 (2026)

Edited by

Rashmi Laddha

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.