Title
Authors
Habibatou Diabate1, Clifton Mason Perry2, Sajidha Nizamudeen3, Oluwatobi Onalaja2, Sabah Fatima4, Ram Vikas Reddy5, Mohammed Hady Albitar6,*, Abdullah Almahmoud7, Alana Rivera Negrón8, Harsh Vijay Sanghvi9 & Mohammed Abdul Mateen10
Affiliation
1Department of Internal Medicine, American University of the Caribbean school of medicine, Sint Maarten; 2Department of Internal Medicine, Ross University School of Medicine, Miramar, Florida, USA; 3Department of Internal Medicine, Travancore Medical College, Kerala, India; 4Department of Internal Medicine, KBN University, Khaja Banday Nawaz medical college, Kalaburagi, Karnataka, India; 5Department of Internal Medicine, NRI Medical College, Guntur, India; 6Department of Internal Medicine, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; 7Department of Medicine, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia;8Department of Internal Medicine, University of Medicine and Health Sciences, Basseterre, St. Kitts & Nevis; 9Department of Internal Medicine, Georgian National University SEU, Tblisi, Georgia; 10Department of Anaesthesia, Mahavir Institute of Medical Sciences, Vikarabad, India; *Corresponding author
Habibatou Diabate - E-mail: diabatesagoye@gmail.com
Clifton Mason Perry - E-mail: mason_perry@alumni.baylor.edu
Sajidha Nizamudeen - E-mail: sajidhanizamudeen@gmail.com
Oluwatobi Onalaja - E-mail: oluwatobionalaja@mail.rossmed.edu
Sabah Fatima – E-mail: sabahfatima1995@gmail.com
Ram Vikas Reddy- E-mail: ramvikas50@gmail.com
Mohammed Hady Albitar - E-mail: malbitar@alfaisal.edu
Abdullah Almahmoud - E-mail: abdullahfjalmahmoud@gmail.com
Alana Rivera Negrón - E-mail: alarivne@gmail.com
Harsh Vijay Sanghi - E-mail: hsanghvi.0804@gmail.com
Mohammed Abdul Mateen - E-mail: mateenmohdabdul96@gmail.com
Article Type
Research Article
Date
Received June 1, 2026; Revised June 30, 2026; Accepted June 30, 2026, Published June 30, 2026
Abstract
Obesity is associated with hepatic dysfunction, chronic inflammation and vitamin D deficiency, but their interrelationship remains incompletely understood. Therefore, it is of interest to compare the liver function, inflammatory and vitamin D–PTH biomarkers between 100 obese adults (BMI ≥30 kg/m˛) and 100 age-matched non-obese controls. Obese participants showed significantly higher ALT, AST, ALP, GGT, CRP, IL-6, fibrinogen and PTH levels, with lower serum 25(OH)D concentrations. Regression analysis identified CRP (OR=1.38, 95% CI: 1.24–1.54) and GGT (OR=1.35, 95% CI: 1.20–1.52) as the strongest positive predictors, while 25(OH)D showed a significant inverse association with obesity (OR=0.79, 95% CI: 0.68–0.91). Thus, data shows the combined contribution of hepatic dysfunction, systemic inflammation and vitamin D imbalance to obesity-related metabolic disturbances and support their early clinical assessment.
Keywords
Obesity; vitamin D; liver enzymes; inflammatory biomarkers; non-alcoholic fatty liver disease (NAFLD)
Citation
Diabate et al. Bioinformation 22(6): 3469-3475 (2026)
Edited by
Ruby Singh
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
