Title
Platelet indices as prognostic markers of vascular complications in type-2 diabetes mellitus
Authors
Anita Omhare1, Kanhaiya Lal Mishra1, Medha Misra1,*, Preeti Verma2, Sandeep Kumar3 & Prashant Kumar4
Affiliation
1Department of Pathology, Dr. Bhimrao Ramji Ambedkar Government Medical College, Kannauj, Uttar Pradesh, India; 2Department of Community Medicine, Dr. Bhimrao Ramji Ambedkar Government Medical College, Kannauj, Uttar Pradesh, India; 3Department of Community Medicine, Autonomous State Medical College, Kaushambi, Uttar Pradesh, India; 4Department of Multidisciplinary Research Unit, Dr. Bhimrao Ramji Ambedkar Government Medical College, Kannauj, Uttar Pradesh, India; *Corresponding author
Anita Omhare - E-mail: anitaomhare@gmail.com
Kanhaiya Lal Mishra - E-mail: mishra.kanhaiya@gmail.com
Medha Misra - E-mail: pathologygmckannauj2020@gmail.com; Phone: 8923681397
Preeti Verma - E-mail: dr.preetivermakgmc2002@gmail.com
Sandeep Kumar - E-mail: sdkumar96@gmail.com
Prashant Kumar - E-mail: prashantshakyaknj2016@gmail.com
Article Type
Research Article
Date
Received June 1, 2026; Revised June 30, 2026; Accepted June 30, 2026, Published June 30, 2026
Abstract
With its rising incidence and substantial risk of microvascular and macrovascular consequences, diabetes mellitus (DM) is a serious health concern of global magnitude. Therefore, it is of interest to determine the distribution of platelet indices in type 2 diabetes mellitus (T2DM) patients with and without vascular complications and assess their potential as predictive biomarkers. The cross-sectional study was undertaken over 18 months, which included 107 diagnosed T2DM patients and 69 age and gender-matched healthy controls. Platelet count and MPV were significantly altered in diabetics, especially among those with complications, whereas PDW showed no significant difference and logistic regression displayed a significant correlation of abnormal platelet count (Adjusted OR: 2.95, 95% CI: 1.23–7.06; p=0.015) and MPV (Adjusted OR: 0.31, 95% CI: 0.10–0.92; p=0.036) with vascular complications. Platelet count and MPV are promising, economical biomarkers for the early prediction of vascular complications in T2DM patients and their frequent monitoring may lead to early disease detection, timely management and better clinical outcomes.
Keywords
Mean platelet volume (MPV), platelet count (PC), platelet indices, type 2 diabetes mellitus (T2DM), vascular complications
Citation
Omhare et al. Bioinformation 22(6): 3486-3490 (2026)
Edited by
Rashmi Laddha
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
