Title

C - reactive protein to albumin ratio as predictor of severity and outcome in acute pancreatitis

Authors

Umesh Pratap Singh¹, Manzar Hussain Usmani², Mukund Pandey³ & Pooja Patel^1,*

Affiliation

¹Department of General Medicine, Shyam Shah Medical College and Associated Sanjay Gandhi Memorial Hospital, Rewa, Madhya Pradesh, India; ²Department of Gastroenterology, Shyam Shah Medical College and Associated Sanjay Gandhi Memorial Hospital, Rewa, Madhya Pradesh, India; ³Department of General Surgery, Shyam Shah Medical College and Associated Sanjay Gandhi Memorial Hospital, Rewa, Madhya Pradesh, India; *Corresponding author

Email

Umesh Pratap Singh - E-mail: upsingh87@gmail.com; Phone: +91 9136464178

Manzar Hussain Usmani - E-mail: manzar.usmani@gmail.com; Phone: +91 9826143407

Mukund Pandey - E-mail: mukundpandey25@gmail.com; Phone: +91 8770377955

Pooja Patel - E-mail: pp60635@gmail.com; Phone: +91 8962338998

Article Type

Research Article

Date

Received June 1, 2026; Revised June 30, 2026; Accepted June 30, 2026, Published June 30, 2026

Abstract

Early and accurate prediction of severity in acute pancreatitis remains a major clinical challenge, particularly in resource-limited settings. Hence, this cross-sectional study evaluated 100 patients to assess the prognostic value of the CRP/Albumin ratio (CAR) in comparison with BISAP and other parameters. Disease severity was mild in 40%, moderate in 30% and severe in 30%, with ICU admission in 23% and overall mortality of 5%, increasing with severity. Non-survivors had significantly higher age (62.6 ± 7.09 vs 40.41 ± 13.66 years), urea (78.72 ± 66.08 vs 24.09 ± 13.99 mg/dL), creatinine (2.69 ± 1.68 vs 0.84 ± 0.43 mg/dL), CRP (182.61 ± 141.55 vs 75.98 ± 82.76 mg/L), CAR (107.18 ± 106.30 vs 28.09 ± 38.10) and BISAP scores (4.6 ± 0.55 vs 0.85 ± 0.99), along with lower albumin levels (2.11 ± 0.87 vs 3.20 ± 0.98 g/dL). Thus, BISAP showed the highest predictive accuracy (AUC = 1.000), followed by creatinine (0.985), age (0.952) and CAR (0.930).

Keywords

Acute pancreatitis (AP), serum albumin, serum lipase, C - reactive protein (CRP)/albumin ratio

Citation

Singh et al. Bioinformation 22(6): 3521-3526 (2026)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.