Title
Amniotic membrane for oral surgical defect coverage: A clinical study
Authors
Meenakshi Kothari*, Satishkumar G. Patil, Ashwin Shah, Udupikrishna Joshi & Chaitanya Kothari
Affiliation
Department of Oral and Maxillofacial Surgery, H.K.E’s S. Nijalingappa Institute of Dental Sciences and Research Centre, Kalaburagi, Karnataka, India; *Corresponding author
Meenakshi Kothari - E-mail: drmeenakshi.kothari@gmail.com; Phone: +91 9972317474
Satishkumar G. Patil - E-mail: satpat71@gmail.com; Phone: +91 9448124464
Ashwin Shah - E-mail: drashwinshah1981@gmail.com; Phone: +91 9241045506
Udupikrishna Joshi - E-mail: dr_udupijoshi@yahoo.com; Phone: +91 9019085985
Chaitanya Kothari - E-mail: chaitanya.kothari@gmail.com; Phone: +91 9972081338
Article Type
Research Article
Date
Received June 1, 2026; Revised June 30, 2026; Accepted June 30, 2026, Published June 30, 2026
Abstract
Reconstruction of oral soft-tissue defects remains limited by donor-site morbidity and inconsistent healing with currently available grafts. In this prospective interventional study, we assessed human amniotic membrane (HAM) as a biologically active scaffold in 15 patients (6 cleft alveolus, 2 oral submucous fibrosis, 7 vestibuloplasty; ages 8–65 years). HAM integrated without complications in all cases, with no necrosis, infection, or immunologic rejection; median pain (VAS) fell from 2 on day 1 to 0 by day 7 (p < 0.00001) and swelling resolved by day 7 (p < 0.00001). Epithelialization reached "good" by 1 month (p < 0.00001); mucosal suppleness remained preserved through 6 months and in OSMF cases interincisal opening improved to 35–50 mm. Thus, data shows the HAM as a safe, donor-site–sparing, clinically translatable biomaterial that accelerates healing and improves function in oral soft-tissue reconstruction.
Keywords
Amniotic membrane (AM), vestibuloplasty, cleft alveolus, oral submucous fibrosis
Citation
Kothari et al. Bioinformation 22(6): 3527-3533 (2026)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
