Title

Linking oral microbiome with mental health: A review

Authors

Maleha Maleha*

Affiliation

Researcher, Tact Force, Jacksonville, Florida, 32257, USA; *Corresponding author

Email

Maleha - E-mail: malehak317@tactforce.ca; Phone: +1 (904) 423-6485

Article Type

Review

Date

Received June 1, 2026; Revised June 30, 2026; Accepted June 30, 2026, Published June 30, 2026
 

Abstract

The gut microbiome shapes depression and anxiety, yet the oral microbiome that seeds it daily remains overlooked. Therefore, it is of interest to review on the oral microbiome's role in the gut–brain axis. A reproducible signature emerges: enriched Prevotella with depleted Haemophilus and Rothia. Four pathways connect a dysbiotic mouth to the brain inflammation, bacterial translocation, neurotransmitter signalling and HPA-axis dysregulation. As adults see hygienists more than any other clinician, dental visits could screen, prevent and refer along this axis.

Keywords

Oral microbiome, mental health, depression, anxiety, gut–brain axis, dental hygiene, microbial biomarkers, oral dysbiosis, Prevotella, Haemophilus, Rothia

Citation

Maleha et al. Bioinformation 22(6): 3667-3672 (2026)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.