Title
Comparative efficacy and cytocompatibility of antimicrobial nanocoatings versus antibiotics on titanium dental implant surfaces
Authors
Maitreyi Ranjan1,*, Shailesh Jain2, Nikhil Prakash3, Monika Sinha4, Shabnam Chaudhary5 & Roli Singh6
Affiliation
1Department of Microbiology, School of Dental Sciences, Sharda University, Greater Noida, Uttar Pradesh, India; 2Department of Dentistry, GEIMS, Dehradun, Uttarakhand, India; 3Department of Prosthodontics, Crown and Bridge, DJ College of Dental Sciences and Research, Modinagar, Uttar Pradesh, India; 4Department of Dentistry, Private Practitioner, Flora Dental care, Bangalore, India; 5Department of Dentistry, PHC Jahu, Hamirpur, Himachal Pradesh, India; 6Department of Oral and Maxillofacial Pathology and Microbiology, Visiting consultant, Gupta Dental Care, Aligarh, India; *Corresponding authors
Maitreyi Ranjan- E-mail: maitreyi.ranjan@sharda.ac.in
Shailesh Jain - E-mail:shaileshbluedoct@gmail.com
Nikhil Prakash - E-mail:drnikhillko@gmail.com
Monika - E-mail:drmonikasinha@yahoo.com
Shabnam Chaudhary- E-mail:dr.shabnam1996@gmail.com
Roli Singh - E-mail:rolisingh786@gmail.com
Article Type
Research Article
Date
Received June 1, 2026; Revised June 30,
2026; Accepted June 30, 2026, Published June 30, 2026
Abstract
Bacterial colonization resulting in peri-implantitis is a significant issue in dental implantology which results in an implant failure. Therefore, it is of interest to evaluate the antimicrobial efficacy and cytocompatibility of nanoparticle-based-coatings and conventional antibiotic-coatings on the titanium dental implant surfaces were compared. The determination of the cytocompatibility between human osteoblast-like cells (MG-63) was done in terms of MTT assay, cell proliferation and adhesion. AgNP coating was found to be more effective at antimicrobial efficacy against all bacteria studied (18.6±1.4 mm with S. aureus) than gentamicin (14.2±1.1 mm) and ZnO-NP (12.8±1.3 mm). Thus, data shows the nanoparticle-based coatings especially AgNPs have better antimicrobial effects with retained biocompatibility.
Keywords
Titanium dental implants, silver nanoparticles (AgNP), zinc oxide nanoparticles (ZnO-NP), antimicrobial coating, cytocompatibility, peri-implantitis
Citation
Ranjan et al. Bioinformation 22(6): 3712-3717 (2026)
Edited by
Vini Mehta
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
