Title

Comparison of 1% alendronate gel versus 1.5% chlorhexidine gel (chlosite) as an adjunct to the scaling and root planning in treating chronic periodontitis - A randomized controlled trial

Authors

Rupali Ravindra Borade^1,*, Saurabh Patil¹, Abhishek Kurdukar², Moitri Ojha¹, Apeksha Birla³ & Mithila Mane⁴

Affiliation

¹Department of Periodontology, SMBT dental college & hospital, Sangamner, Maharashtra, India; ²Department of Periodontology, SMBT Institute of Dental Sciences and Research, Dhamangaon, Nashik, Maharashtra, India; ³Department of Periodontology & Implantology, Smart life polyclinic, Dubai, United Arab Emirates; ⁴Department of Periodontology, Bellevue Medical Centre, Dubai, United Arab Emirates; *Corresponding author

Email

Rupali Ravindra Borade - E-mail:boraderupali92@gmail.com

Saurabh Patil - E-mail:dr.saurabh.subhash.patil@gmail.com

Abhishek Kurdukar - E-mail:drabhikurdukar@gmail.com

Moitri Ojha - E-mail: moitriojha@yahoo.in

Apeksha Birla - E-mail: drbirla77@gmail.com

Mithila Mane - E-mail:dr.mithilamane@gmail.com

Article Type

Research Article

Date

Received July 1, 2026; Revised July 31, 2026; Accepted July 31, 2026, Published July 31, 2026
 

Abstract

Local drug delivery is a promising non-surgical alternative to SRP for treating chronic periodontitis patients. Therefore, it is of interest to analyse the effectiveness of 1% Alendronate gel, 1.5% Chlorhexidine gel as an adjunct to scaling and root planing. Twenty participants were enrolled and distributed among three groups: Test Group A treated with SRP+1% alendronate gel, Test Group B treated with SRP+1.5% chlorhexidine gel and Control Group C treated with SRP alone. Periodontal parameters like PI, GI, SBI, CAL and PPD were noted at baseline, 3 and 6 months postoperatively. Remarkable reduction of all parameters was observed in all 3 groups from the beginning of treatment to 3-month to 6-month interval, whereas, no difference was observed in control Group C for PD scores and CAL gain. On intergroup comparison of PI, GI, SBI scores test, group B shows highly significant differences in comparison to test Group A and control Group C at 3 and 6-month intervals (P < 0.001). Thus, data shows the chlorhexidine gel as LDD is efficacious in treating periodontal pocket, whereas 1% alendronate gel, along with SRP, can be used as an alternative for treating chronic periodontitis.

Keywords

Periodontitis, local drug delivery (LDD), chlosite, alendronate, bisphosphonates

Citation

Borade et al. Bioinformation 22(7): 3854-3858 (2026)

Edited by

Rashmi Laddha

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.