Title

Correlation between serum magnesium and glycemic control among type 2 diabetes patients

Authors

B. Jayakrishnan^1,*, Kapil Khanna², Shubham Saxena³, Sangeeta Gupta⁴, Parth Jani⁵ & Ria Singh Rawat⁶

Affiliation

¹Department of Medicine, Educare Institute of Dental Sciences, Malappuram, India; ²Department of Physiology, Santosh Deemed to be University, Ghaziabad, Uttar Pradesh, India; ³Department of community medicine, Govt. Bundelkhand medical College Sagar, Madhya Pradesh, India; ⁴Department of Physiology, AIIMS Gorakhpur, Uttar Pradesh, India; ⁵Department of General Medicine, Government Medical College, Bhavnagar, India; ⁶Department of Emergency, BGS GIMS, Karnataka, India; *Corresponding author

Email

B. Jayakrishnan - E-mail: jaykdr@gmail.com

Kapil Khanna - E-mail: kapil76khanna@gmail.com

Shubham Saxena - E-mail: drshubhamsaxena@gmail.com

Sangeeta Gupta - E-mail: drsangeeta77.65@rediffmail.com

Parth Jani - E-mail: parthjani13@gmail.com

Ria Singh Rawat - E-mail:  riasinghrawat18@gmail.com

Article Type

Research Article

Date

Received July 1, 2026; Revised July 31, 2026; Accepted July 31, 2026, Published July 31, 2026
 

Abstract

Hypomagnesemia is increasingly recognized as a significant yet underappreciated comorbidity in type 2 diabetes mellitus (T2DM), with emerging evidence suggesting its role in impaired insulin signaling and worsening glycemic outcomes. Therefore, it is of interest to investigate the correlation between serum magnesium levels and markers of glycemic control including glycated hemoglobin (HbA1c), fasting blood glucose (FBG) and postprandial blood glucose (PPBG) in 120 T2DM patients. Serum magnesium levels were significantly lower in patients with poor glycemic control and a strong inverse correlation was observed between serum magnesium and HbA1c (r = −0.68, p<0.001). The overall prevalence of hypomagnesemia was 45%, with rates rising progressively across worsening glycemic categories. Thus, data shows the clinical importance of monitoring serum magnesium as part of routine diabetic management to potentially improve long-term glycemic outcomes.

Keywords

Serum magnesium, type 2 diabetes mellitus (T2DM), glycemic control, glycated hemoglobin (HbA1c), hypomagnesemia, insulin resistance

Citation

Jayakrishnan et al. Bioinformation 22(7): 3920-3923 (2026)

Edited by

Ruby Singh

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.