Title
Linking between blood groups and dental caries - A review
Authors
Satyam Lahoti*, Preetam Shah, Shweta Chaudhary, Laxmi Lakade, Shweta Jajoo & Chetana Jagtap
Affiliation
Department of Pediatric and Preventive Dentistry, BharatiVidyapeeth Dental College and Hospital, Pune, India; *Corresponding author
Satyam Lahoti - E-mail: satyam.lahoti-dchpune@bvp.edu.in
Preetam Shah - E-mail: preetam.shah@bharatividyapeeth.edu
Shweta Chaudhary - E-mail: shweta.chaudhary@bharatividyapeeth.edu
Laxmi Lakade - E-mail: laxmi.lakade@bharatividyapeeth.edu
ShwetaJajoo - E-mail: shweta.jajoo@bharatividyapeeth.edu
ChetanaJagtap - E-mail: chetana.jagtap@bharatividyapeeth.edu
Article Type
Review
Date
Received July 1, 2026; Revised July 31, 2026; Accepted July 31, 2026, Published July 31, 2026
Abstract
Despite extensive research on behavioral and environmental determinants of dental caries, the role of host genetic factors such as the ABO blood group system remains inadequately characterized, leaving a critical gap in individualized caries risk assessment. Therefore, it is of interest to evaluate the association between ABO blood groups and dental caries susceptibility, while exploring the underlying immunological, microbial and genetic mechanisms. A consistent trend emerges from the literature showing higher caries burden among individuals with blood groups B and AB, attributed to reduced salivary IgA levels, enhanced bacterial adhesion mediated by non-O blood group antigens and differences in secretor status. Individuals with blood groups O and A appear comparatively less susceptible, possibly due to superior mucosal immune defense and less favorable antigen-mediated microbial binding sites. Thus, data shows the ABO blood group antigens to caries pathogenesis, establishing a rationale for incorporating genetic profiling into personalized preventive dentistry protocols.
Keywords
ABO blood group, dental caries, salivary immunoglobulin A, caries susceptibility, oral microbiome
Citation
Lahoti et al. Bioinformation 22(7): 3969-3974 (2026)
Edited by
Neelam Goyal & Shruti Dabi
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
