Title
Clinical evaluation of concentrated growth factor membrane versus platelet-rich fibrin membrane following periodontal flap surgery
Authors
Maya S. Indurkar, Chandulal D. Dhalkari, Pawan M. Hargunani*, Sandhya Rathod, Rashmi S. Dadmal & Shubham P. Pande
Affiliation
Department name is missing, Government Dental College and Hospital, GHATI Campus, Panchakki Road, Chhatrapati Sambhajinagar, Maharashtra, India; * Corresponding author
Maya S. Indurkar - E-mail: maya.indurkar@gov.in; Phone: +91 9823182694
Chandulal D. Dhalkari - E-mail: dr.cddhalkari@gov.in; Phone: +91 9422204639
Pawan M. Hargunani - E-mail: hargunani.pawan@gmail.com; Phone: +91 9975053081
Sandhya Rathod - E-mail: sandhyarathod84@gmail.com; Phone: +91 9890167770
Rashmi S. Dadmal - E-mail: rsdadmal.rd@gmail.com; Phone: +91 7588962239
Shubham P. Pande - E-mail: drshubhampande@gmail.com; Phone: +91 8788244498
Article Type
Research Article
Date
Received July 1, 2026; Revised July 31, 2026; Accepted July 31, 2026, Published July 31, 2026
Abstract
Achieving predictable wound healing after periodontal flap surgery remains a clinical challenge despite advances in regenerative therapy. Therefore, it is of interest to compare the effectiveness of concentrated growth factor (CGF) and platelet-rich fibrin (PRF) membranes in enhancing post-operative wound healing in 14 patients with Stage III Grade B periodontitis. Early wound healing and post-operative pain were assessed on the seventh post-operative day using the Early Wound Healing Index (EWHI) and Visual Analogue Scale (VAS). The CGF group demonstrated significantly better early wound healing than the PRF group (EWHI: 4.14 vs. 3.29; p=0.045), while post-operative pain was comparable between the groups (VAS: 3.86 vs. 4.00; p=0.829). Thus, data shows the CGF membrane may provide superior early periodontal wound healing following flap surgery, although larger randomized clinical trials are required to confirm its clinical benefits.
Keywords
Concentrated growth factor (CGF) membrane, platelet-rich fibrin (PRF) membrane, periodontal dressing, wound healing index, Visual Analogue Scale (VAS), epithelialization
Citation
Indurkar et al. Bioinformation 22(7): 4077-4081 (2026)
Edited by
Hiroj Bagde
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
