Title

Assessment of antimicrobial photodynamic therapy as an adjunct to scaling and root planing in periodontitis patients: A randomized controlled clinical study

Authors

Pransi Gupta*, Ellora Madan, Kratee Sharma, Tabinda Khan, Kalpit Rai & Shivi Mittal

Affiliation

Department of Periodontology Kothiwal Dental college and Research centre, Moradabad, Uttar Pradesh, India; *Corresponding author

Email

Pransi Gupta - E-mail: pransi1997gupta@gmail.com

Ellora Madan - E-mail: ellorabhattmadan@gmail.com

Kratee Sharma - E-mail: drkratee@gmail.com

Tabinda Khan - E-mail: khantabinda48415@gmail.com

Kalpit Rai - E-mail: k786rai786@gmail.com

Shivi Mittal - E-mail: shivimittal5678@gmail.com

Article Type

Research Article

Date

Received July 1, 2026; Revised July 31, 2026; Accepted July 31, 2026, Published July 31, 2026

Abstract

Periodontitis remains a major clinical challenge because conventional scaling and root planing (SRP) alone may not completely eliminate pathogenic microorganisms from periodontal pockets. Therefore, it is of interest to evaluate the efficacy of antimicrobial photodynamic therapy (a-PDT) using indocyanine green activated by a diode laser and erythrosine activated by LEDs as adjuncts to SRP in 15 patients with periodontitis. Clinical parameters including plaque index (PI), modified sulcular bleeding index (mSBI), probing pocket depth (PPD) and clinical attachment level (CAL) were assessed at baseline, 15 days and 3 months. All groups demonstrated significant improvements over time (p<0.001), with the indocyanine green–diode laser group showing significantly greater reductions in PI, mSBI and PPD and greater CAL gain than the erythrosine–LED and SRP-alone groups. Thus, data shows that indocyanine green-mediated a-PDT used with a diode laser is a more effective adjunct to SRP for improving clinical periodontal outcomes.

Keywords

Antimicrobial photodynamic therapy (a-PDT), indocyanine green dye, erythrosine dye, light amplification by stimulation of radiation, light emitting diode, scaling and root planing (SRP)

Citation

Gupta et al. Bioinformation 22(7): 4116-4121 (2026)

Edited by

Hiroj Bagde

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.