Title
Comparative evaluation of olanzapine and risperidone in schizophrenia patients using the positive and negative syndrome scale
Authors
Shruti Vihang Brahmbhatt, Aryan Pankajkumar Patel* & Mahavirsingh Rajput
Affiliation
Department of Pharmacology, Shrimati Bhikhiben Kanjibhai Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed to be University, Vadodara - 391760, Gujarat, India; *Corresponding author
Author contact: Shruti Vihang Brahmbhatt - E-mail: dr.shruti1988@gmail.com
Aryan Pankajkumar Patel - E-mail: aryanpatel.ap1999@gmail.com; Phone: +91 9925224674
Mahavirsingh Rajput - E-mail: drvirranawat@gmail.com
Article Type
Research Article
Date
Received July 1, 2026; Revised July 31, 2026; Accepted July 31, 2026, Published July 31, 2026
Abstract
Schizophrenia is a chronic psychiatric disorder associated with substantial disability, persistent symptom burden and premature mortality. Therefore, it is of interest to compare the 12-week effectiveness and safety of olanzapine and risperidone monotherapy in 40 newly diagnosed patients with schizophrenia-spectrum disorders in a rural Indian tertiary-care setting. Both groups showed significant clinical improvement, but olanzapine showed greater reduction in PANSS positive, negative and total scores by month three, with total PANSS scores of 62.1 ± 8.7 versus 69.3 ± 9.4 in the risperidone group. Olanzapine was associated with greater mean weight gain and more weight-related adverse events, whereas risperidone was associated with a higher frequency of extrapyramidal symptoms. Thus, data shows the importance of antipsychotic selection based on expected efficacy, metabolic risk, and neurological tolerability and structured follow-up monitoring.
Keywords
Schizophrenia; olanzapine; risperidone; positive and negative syndrome scale (PANSS); negative symptoms; extrapyramidal symptoms; weight gain; prospective observational study
Citation
Brahmbhatt et al. Bioinformation 22(7): 4187-4192 (2026)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
