Title
Role of immunohistochemical p53 expression as a prognostic marker in molar pregnancy
Authors
Tasrina Akter1,*, Abu Bakar Muhammad Nizamul Hoque Sikder2, Fahmida Sultana Mili3, Rezowana Afrin4, Shahana Begum3, Roushan Akhter Jahan3 & Shahena Akter3
Affiliation
1Department of Obstetrics and Gynaecology, Nottingham University Hospital, United Kingdom; 2Department of Stroke, Nottingham University Hospital, United Kingdom; 3Department of Obstetrics and Gynaecology, Chittagong Medical College Hospital, Chittagong, Bangladesh, India; 4Department of Obstetrics and Gynaecology, Peterborough City Hospital, United Kingdom; *Corresponding author
Tasrina Akter - E-mail: tasrina.hameed@gmail.com
Abu Bakar Muhammad Nizamul Hoque Sikder - E-mail: sikder45@yahoo.com
Fahmida Sultana Mili - E-mail: sfahmida84.fsm@gmail.com
Rezowana Afrin - E-mail: rez2tanya@gmail.com
Shahana Begum - E-mail: drshahanashelly@gmail.com
Roushan Akhter Jahan - E-mail: roushanjahan2012@gmail.com
Shahena Akter - E-mail: shahena.cmc27@gmail.com
Article Type
Research Article
Date
Received July 1, 2026; Revised July 31, 2026; Accepted July 31, 2026, Published July 31, 2026
Abstract
Malignant transformation of hydatidiform mole remains difficult to predict using conventional clinical parameters alone. A cross sectional analytical study of 50 women showed significantly higher p53 expression in cases with elevated β-hCG levels and subsequent malignant progression. ROC analysis showed excellent predictive performance (AUC=0.938), with 87.5% sensitivity and 71.3% specificity at a 42.5% stained-cell cut-off. All patients with malignant progression showed positive p53 staining (p=0.018). Thus, data shows p53 immunoexpression as a promising prognostic biomarker for early risk stratification and clinical management of molar pregnancy.
Keywords
p53, molar pregnancy, hydatidiform mole (HM), gestational trophoblastic neoplasia (GTN), immunohistochemistry
Citation
Akter et al. Bioinformation 22(7): 4230-4233 (2026)
Edited by
Ritik Kashwani
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
