Title
i-PRF, diode laser and hyaluronic acid in chronic periodontitis: A comparative clinical study
Authors
Aditi Pandey, Vivek Srivastava*, Amitabh Srivastava, Ajita Meenawat, Tanu Sahney & Elizabeth Huidrom
Affiliation
Department of Periodontology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India; *Corresponding author
Aditi Pandey - E-mail: dr.aditi.perio@gmail.com
Vivek Srivastava - E-mail: drviveksrivastav89@gmail.com
Amitabh Srivastava - E-mail: docamitabh74@gmail.com
Ajita Meenawat - E-mail: ajita.meenawat@gmail.com
Tanu Sahney - E-mail: tanu.sahney910@gmail.com
Elizabeth Huidrom - E-mail: elizabethhuidrom16@gmail.com
Article Type
Research Article
Date
Received July 1, 2026; Revised July 31, 2026; Accepted July 31, 2026, Published July 31, 2026
Abstract
Delayed or unfavorable periodontal wound healing after flap surgery is a clinical problem that can affect post-operative comfort and long-term periodontal outcomes. Therefore, it is of interest to evaluate the effect of adjunctive i-PRF, diode laser and hyaluronic acid with open flap debridement in ten patients diagnosed with chronic periodontitis. Pain using VAS score and early wound healing score were assessed at 24 hours, 3 days and 7 days, while plaque index, gingival index, probing pocket depth and clinical attachment level were recorded at baseline, 1 month and 3 months. All treatment groups showed improvement in clinical parameters, with Group C receiving diode laser adjunctive therapy demonstrating better VAS, EHS, PPD and CAL outcomes than the other groups. Thus, data shows that adjunctive use of i-PRF, diode laser and hyaluronic acid with open flap debridement may improve periodontal healing, although larger studies with longer follow-up are required for validation.
Keywords
Chronic periodontitis (CP), periodontal debridement, platelet-rich fibrin (i-PRF), hyaluronic acid, laser, wound healing
Citation
Pandey et al. Bioinformation 22(7): 4319-4324 (2026)
Edited by
Hiroj Bagde
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
