Title
Latent toxicity of alcohol
Authors
L. Konieczny, I. Roterman* & P. Spolnik
Affiliation
Department of Medical Biochemistry Jagiellonian University, Medical College, 31-034 Krakow, Kopernika 7, Poland; *Corresponding author
L. Konieczny - E-mail: mbkoniec@cyf-kr.edu.pl
I. Roterman - E-mail: myroterm@cyf-kr.edu.pl
P. Spolnik - E-mail: pspolnik@cm-uj.krakow.edu.pl
Article Type
Editorial
Date
Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026
Abstract
Ingested alcohol revels its effect directly by impacting the central nervous system arising from solubility in water and fats. As alcohol infiltrates into cells disturbing the environmental conditions by lowering the dielectric constant and in consequence reveals significant negative impact on environment-controlled cellular processes like all self-organisation processes. Protein folding, the formation of their functional forms and the formation of biological membranes are particularly important as appearing to be environment dependent. It may be proven by the fuzzy oil drop model interpreting the folding process as significantly dependent of the external conditions. The low-degree misfolded proteins - unrecognised in normal conditions - develop dementia, life-shortening as well as atherosclerosis, diabetes and lowered cellular and humoral immunity after reaching the higher level disorganisation.
Keywords
Protein folding, alcohol, protein synthesis, self-organisation, atherosclerosis
Citation
Konieczny et al. Bioinformation 22(8): 4605-4610 (2026)
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
