Title

Immediate implant placement in extraction sockets using i-PRF–enhanced bone grafts and amniotic membrane with zirconia crown rehabilitation: A clinical and digital radiographic evaluation

Authors

Swapnaneel Pradhan^1,*, Ravi Kunnaiah², Vineeth A. Dixit³, Kancharla Sunitha⁴, Megha vanasi⁵, Neha Mangla⁶, Md Kafeel Ahmed⁷ & Rubeena Naaz⁸

Affiliation

¹Department of Prosthodontics, Geetanjali Dental and Research Institute, Geetanjali University, Udaipur, Rajasthan, India; ²Department of Periodontics, MES Dental College and Hospital, Perinthalmanna, Mallapuram District, Kerala 679322, India; ³Department of Prosthodontics and Implantology, K.L.E Society's Institute of Dental Sciences, Bengaluru, India; ⁴Department of Oral and Maxillofacial Surgery, Malla Reddy Institute of Dental Sciences, Malla Reddy Vishwavidyapeeth (deemed to be university), Suraram, Hyderabad, Telangana, India; ⁵Department of Periodontology, Faculty of Dental Science, Dharmsinh Desai university, Nadiad, India; ⁶Department of Conservative Dentistry and Endodontics, Sudha Rustagi college of Dental Science and Research, Faridabad, Haryana, India; ⁷Department of Periodontology, MNR Dental College and Hospital Sangareddy, Telangana, India; ⁸Department of Dentistry, SRK Dental Clinic, Hyderabad, India; *Corresponding author

Email

Swapnaneel Pradhan - E-mail: dr.swapnaneel@gmail.com
Ravi Kunnaiah - E-mail: ravimesdch@gmail.com
Vineeth A. Dixit - E-mail: vineethadixit21@gmail.com
Kancharla Sunitha - E-mail: sunithakancharla94@gmail.com
Megha vanasi - E-mail: meghavanasi.fods@ddu.ac.in
Neha Mangla - E-mail: rajendersingla84@gmail.com
Md Kafeel Ahmed - E-mail: drkafeelsohar@gmail.com
Rubeena Naaz - E-mail: rubeenakhan412@gmail.com

Article Type

Research Article

Date

Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026

Abstract

Immediate implant placement remains challenged by marginal bone loss and peri-implant soft tissue instability despite its clinical advantages. Therefore, it is of interest to evaluate the effectiveness of i-PRF–enhanced bone grafts combined with amniotic membrane in 100 patients undergoing immediate implant placement and zirconia crown rehabilitation. Patients receiving i-PRF, bone graft and amniotic membrane showed significantly better plaque index, gingival index, probing depth, implant stability and marginal bone preservation than those receiving bone grafts alone (p < 0.05). The adjunctive use of i-PRF and amniotic membrane improved both clinical and radiographic outcomes during the 6-month follow-up period. Thus, combining i-PRF with amniotic membrane may enhance peri-implant tissue regeneration and implant stability, improving the predictability of immediate implant therapy.

Keywords

Immediate implant placement, Injectable platelet-rich fibrin (i-PRF), bone graft, amniotic membrane, zirconia crown

Citation

Pradhan et al. Bioinformation 22(8): 4611-4616 (2026)

Edited by

Ritik Kashwani

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.