Title

ADAS-Cog performance in urban Indian Alzheimer's patients: Implications for culturally appropriate assessment

Authors

Aahana Gupta^1,* & Praveen Gupta²

Affiliation

¹Departmnent of Psychology and Biochemistry, Cardiff Sixth Form College, Cardiff, Wales, UK; ²Department of Neurology, Marengo Asia Hospital, Sector 56, Gurugram, Haryana, India; *Corresponding author

Email

Aahana Gupta – E-mail: aahana.gupta.uk@gmail.com
Praveen Gupta – E-mail: drpraveenguptaneuro@gmail.com

Article Type

Research Article

Date

Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026

Abstract

Assessment tools developed for Western populations may not accurately evaluate cognitive impairment in multilingual Indian patients with Alzheimer's disease. Therefore, it is of interest to assess the domain-based performance using the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) among 12 urban Indian patients aged 70–83 years. Memory domains showed the greatest impairment, with the highest scores for Word Recall (4.75±2.96) and Word Recognition (3.75±2.38), whereas language domains such as Comprehension (1.25±0.45) and Word Finding (1.08±0.90) remained relatively preserved. Age showed a significant positive correlation with total ADAS-Cog score (Spearman r=0.65, p=0.022), while education showed no significant association with cognitive impairment. Thus, data shows the cognitive profile of Alzheimer's disease we further emphasize the need for culturally and linguistically adapted cognitive assessment tools for Indian clinical practice.

Keywords

Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), Alzheimer's disease (AD), cognitive assessment, cultural adaptation, multilingual population, neuropsychological testing, memory impairment, word recall, cognitive domains, Indian clinical settings

Citation

Gupta & Gupta, Bioinformation 22(8): 4617-4621 (2026)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.