Title

A clinical study on the effectiveness of Azadirachta indica (neem) as a local drug delivery agent in periodontal disease management

Authors

Dileep Kishore^1,*, Pooja Walia², Sweta Yadav², Manoj Yadav³, Saurabh Yadav³ & Treena Kabiraj¹

Affiliation

¹Department of Periodontology, Dental College Azamgarh, Azamgarh, Uttar Pradesh, India; ²Department of Periodontology, Teerthanker Mahaveer Dental College & Research Centre, Moradabad, Uttar Pradesh, India; ³Department of Pediatric & Preventive Dentistry, Dental College Azamgarh, Azamgarh, Uttar Pradesh, India; *Corresponding author

Email

Dileep Kishore - E-mail: dileepkishor5@gmail.com
Pooja Walia - E-mail: pwalia16dec@gmail.com
Sweta Yadav - E-mail: sweta8yadav@gmail.com
Manoj Yadav - E-mail: manojyadav55667788@gmail.com
Saurabh Yadav - E-mail: yadav.blueblue.02@gmail.com
Treena Kabiraj - E-mail: treenakabiraj@gmail.com

Article Type

Research Article

Date

Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026

Abstract

Periodontal disease remains a major oral health burden and conventional scaling and root planing (SRP) alone often fails to achieve sustained outcomes in advanced cases. Therefore, it is of interest to evaluate the neem based local drug delivery (LDD) formulations including gel, chips and extract irrigation as adjuncts to SRP, compared with SRP alone and chlorhexidine chips. Clinical probing pocket depth (PPD), clinical attachment loss (CAL), gingival index (GI), plaque index (PI) and microbiological (CFU count) parameters were assessed at baseline and after 30 days. Neem based groups showed significant improvements in all parameters, with neem chips showing outcomes comparable to chlorhexidine. Thus, neem-based local drug delivery, particularly neem chips, is an effective, economical and biologically safe adjunct in periodontal therapy.

Keywords

Antimicrobial, anti-inflammatory, Azadirachta indica, local drug delivery, neem, periodontal disease

Citation

Kishore et al. Bioinformation 22(8): 4683-4687 (2026)

Edited by

Ritik Kashwani

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.