Title

Immediate intragastric acid neutralization with botanical granules

Authors

Baidyanath Mishra^1,*, Pankaj Gupta², Ashwini Arora², Akash Shukla³, Anil Deshpande³, Srinivasa Reddy Yathapu⁴, Garima Gupta⁴ & Apratim Sai Rajesh⁴

Affiliation

¹Department of HealthCare R&D, Dabur Research and Development Centre, Dabur, India; ²Department of Ayurveda Formulation, Dabur Research and Development Centre (Healthcare), Dabur, India; ³Department of General Medicine, Tagret Institute of Medical Education and Research, Malad West, Mumbai, India; ⁴Department of Medical Affairs and Clinical Research, Dabur Research and Development Centre (Healthcare), Dabur, India; *Corresponding author

Email

Baidyanath Mishra - E-mail: baidyanath.mishra@dabur.com; Phone: +91 020-337-8606
Pankaj Gupta - E-mail: pankaj.gupta@dabur.com
Ashwini Arora - E-mail: ashwani.arora@dabur.com
Akash Shukla - E-mail: akashshukla.timer@gmail.com
Anil Deshpande - E-mail: anildeshpande.timer@gmail.com
Srinivasa Reddy Yathapu - E-mail: srinivasa.yathapu@dabur.com
Garima Gupta - E-mail: garima.gupta@dabur.com
Apratim Sai Rajesh - E-mail: apratim.rajesh@dabur.com

Article Type

Research Article

Date

Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026

Abstract

Gastroesophageal Reflux Disease (GERD) results from backflow of acidic gastric secretions (pH 1–2) into the oesophagus, for which Dabur India Ltd. developed antacid powder DRDC/2022/040 containing Nimbu Satva (Citrus medica), Peppermint Satva (Mentha piperita) and Sarjikshara (sodium bicarbonate) for acid neutralization. A crossover clinical study (n=32) evaluated intragastric pH via nasogastric probe over 15-minute baseline and 60 minutes post-consumption, with 36–48 hour washout. Group-1 (n=15, DRDC/Water sequence) showed significant pH increase from baseline 1.97 ± 0.55 to 2.56 ± 1.02 at 2 seconds post-DRDC (p<0.05), with no change following water crossover. While Group-2 (n=16, Water/DRDC sequence) showed significant pH increase upon DRDC crossover (baseline 1.67 ± 0.42 to 4.07 ± 1.02 at 10 seconds, p<0.05), versus no change with water. Thus, DRDC/2022/040 exhibits potent antacid activity with onset within 2–3 seconds, effectively neutralizing intragastric acidity.

Keywords

Gastroesophageal Reflux Disease (GERD) symptoms, intragastric pH, antacid, peppermint satva, Citrus medica, sodium bicarbonate

Citation

Mishra et al. Bioinformation 22(8): 4698-4704 (2026)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.