Title
Antimicrobial efficacy of intracanal medicaments targeting E. faecalis biofilm: An in vitro study
Authors
Chirantan Chowdhury*, Abhishek Singh, Sanjeev Kumar Srivastava, Saraswati Sachan & Preeti Rastogi
Affiliation
Department of Conservative Dentistry and Endodontics, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, India; *Corresponding author
Chirantan Chowdhury - E-mail:
chirantanchowdhury06@gmail.com
Abhishek Singh - E-mail: abhishekbaissingh@gmail.com
Sanjeev Kumar Srivastava - E-mail: sanjeevsrivastava409@gmail.com
Saraswati Sachan - E-mail: saraswatisachan90@gmail.com
Preeti Rastogi - E-mail: anuradharstg@gmail.com
Article Type
Research Article
Date
Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026
Abstract
Enteroacoccus faecalis biofilms are a major cause of persistent endodontic infections and treatment failure. Therefore, it is of interest to evaluate and compare the antimicrobial efficacy of triple antibiotic paste, simvastatin, propolis and chitosan against E. faecalis biofilms in extracted human teeth. Antimicrobial activity was assessed by colony-forming unit counts at the apical and middle thirds following medicament application. Chitosan showed the lowest bacterial counts and significantly greater antimicrobial efficacy than the other tested intracanal medicaments. Thus, data show chitosan as a promising biocompatible anti-biofilm agent for intracanal disinfection.
Keywords
Antibiofilm activity, chitosan, enterococcus faecalis, intracanal medicaments, propolis, simvastatin, triple antibiotic paste (TAP)
Citation
Chowdhury et al. Bioinformation 22(8): 4747-4753 (2026)
Edited by
Ritik Kashwani
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
