Title

Comparative evaluation of epidural 0.125% and 0.0625% levobupivacaine with fentanyl for labour analgesia

Authors

Pranay Hedaoo^1,*, Bharti Anjane1, Rani Maran¹, Nisha Panwar² & Karishma Chaurasia³

Affiliation

¹Department of Anaesthesiology, Nandkumar Singh Chouhan Government Medical College, Khandwa, Madhya Pradesh, India; ²Department of Obstetrics and Gynaecology, Nandkumar Singh Chouhan Government Medical College, Khandwa, Madhya Pradesh, India; ³Department of Obstetrics and Gynaecology, Atal Bihari Vajpayee Medical College, Vidisha, Madhya Pradesh, India; *Corresponding author

Email

Pranay Hedaoo - E-mail: pranay.hedaoo@gmail.com
Bharti Anjane - E-mail: bharti.anjane92@gmail.com
Rani Maran - E-mail: ranimarann@gmail.com
Nisha Panwar - E-mail: mandloi.nisha2013@gmail.com
Karishma Chaurasia - E-mail: karishma4015@gmail.com

Article Type

Research Article

Date

Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026

Abstract

Labour pain requires effective epidural analgesia, yet optimal levobupivacaine concentrations balancing sensory relief with minimal motor blockade remain clinically debated. Therefore, it is of interest to compare the 0.125% levobupivacaine-fentanyl versus 0.0625% levobupivacaine-fentanyl in 100 patients, assessing analgesia onset/duration, VAS pain scores, motor block, maternal hemodynamics, labor outcomes and neonatal APGAR scores. Both concentrations provided comparable effective analgesia, but the lower dose (0.0625%) showed reduced motor blockade while maintaining equivalent pain relief profiles. Maternal hemodynamic stability and neonatal APGAR scores showed no significant intergroup differences across both treatment arms. Thus, data shows that establishing lower-concentration levobupivacaine-fentanyl as a safer alternative preserving maternal mobility without compromising labor analgesia efficacy.

Keywords

Labour analgesia, levobupivacaine, epidural analgesia, fentanyl, motor block, obstetric anesthesia

Citation

Hedaoo et al. Bioinformation 22(8): 4916-4920 (2026)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.