Title

An in vitro antifungal evaluation of Schleichera oleosa in superficial mycoses

Authors

Rupendra Chandrakar¹, Chandreshwar Prasad Sinha^2,*, Shrikant Naik¹, Varsha Paikra³, Sushma Rajwade³ & Rajesh Kumar Bharti⁴

Affiliation

¹Department of Samhita Siddhant, Govt. Ayurved college and Hospital Raipur, Chhattisgarh, India; ²Department of Research (Nodal Officer), Pt. Deendayal Upadhyay Memorial Health Science and Ayush University of Chhattisgarh, Raipur, Chhattisgarh, India; ³Department of Kaya Chikitsa, Govt. Ayurved college and Hospital Raipur, Chhattisgarh, India; ⁴Department of Samhita and Siddhant, Chhattisgarh Ayurveda Medical College, Manki, Rajnandgaon, Chhattisgarh, India; *Corresponding author

Email

Rupendra Chandrakar - E-mail: drrupendrac@gmail.com; Phone: +91 9300640932
Chandreshwar Prasad Sinha - E-mail: nodalresearch@ddumhsaucg.ac.in; Phone: +918225000010
Shrikant Naik - E-mail: dr.shrikantnaik@gmail.com; Phone: +91 8823962088
Varsha Paikra - E-mail: paikravarsha69@gmail.com; Phone: +91 9111849706
Sushma Rajwade - E-mail: sushmarajwade45@gmail.com; Phone: +91 7471195649
Rajesh Kumar Bharti - E-mail: 4rajss@gmail.com; Phone: +91 7894807480

Article Type

Research Article

Date

Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026

Abstract

Superficial mycoses remain a common dermatological problem and there is a need for effective, safe and affordable alternative therapies. Therefore, it is of interest to evaluate the antifungal efficacy of Schleichera oleosa compared with terbinafine through both in vitro and clinical investigations. Schleichera oleosa showed superior antifungal activity, producing larger zones of inhibition and lower minimum inhibitory concentration (MIC) values than the standard drug. Clinical evaluation revealed significant symptomatic improvement, with 79% mycological clearance and complete remission in 46.5% of patients. Thus, data shows that Schleichera oleosa is a promising herbal antifungal agent with potential clinical utility in the management of superficial fungal infections.

Keywords

Schleichera oleosa, antifungal study, mycoses, minimum inhibitory concentration (MIC), observational study

Citation

Chandrakar et al. Bioinformation 22(8): 4961-4967 (2026)

Edited by

Ritik Kashwani

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.