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Title

blaIMP and blaOXA mediated carbapenemase resistance in klebsiella pneumoniae: A molecular and phenotypic analysis

 

Authors

Sonali Vijay Bhaisare*

 

Affiliation

Department of Clinical Microbiology, J. N. Medical collage Sawangi, Datta Meghe institute of Higher Education and Research ( Deemed To be University), Sawangi (Meghe), Wardha, Maharashtra, India; *Corresponding author

 

Email

Sonali Vijay Bhaisare - E-mail: bhaisarevsonali@gmail.com; Phone: +91 7083849126

 

Article Type

Research Article

 

Date

Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026

 

Abstract

These effusions result in a convergence of Class B metallo-2-lactamases (blaIMP) and Class D oxacillinases (blaOXA) in Klebsiella pneumoniae to produce very difficult to diagnose and treat complex multidrug-resistant phenotypes. Fifteen phenotypic susceptibility testing and multiplex PCR were performed on 185 carbapenem-resistant K. pneumoniae isolates of a tertiary care center to determine the prevalence and co-occurrence of blaIMP and blaOXA-48-like genes. Molecular genotyping revealed that blaOXA-48-like genes were present in 62.2% of isolates and blaIMP variants in 28.1% with 14.6% of the isolates carrying both genes, which increases the MIC values of imipenem and meropenem by a significant margin over single-gene carriers. Thus, data shows that the development of blaIMP and blaOXA-co-producing strains makes newer 2 2-lactam/2 2-lactamase combinations largely ineffective. This requires the immediate introduction of molecular surveillance and other therapeutic agents such as cefiderocol.

 

Keywords

Klebsiella pneumoniae, Class B metallo-2-lactamases (blaIMP), Class D oxacillinases (blaOXA-48), carbapenemase, multidrug resistance

 

Citation

Bhaisare, Bioinformation 22(8): 4986-4989 (2026)

 

Edited by

Rashmi Laddha

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.