Title
p53 and Ki67 immunoexpression and their clinicopathological correlation in primary gall bladder carcinoma: A cross sectional study
Authors
Hage Nampi1, Ruchi Sinha1, Madhu Kumari1,*, Tarun Kumar1 & Utpal Anand2
Affiliation
1Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences (AIIMS), Patna, Bihar, India; 2Department of Surgical Gastroenterology, All India Institute of Medical Sciences (AIIMS), Patna, Bihar, India; *Corresponding author
Hage Nampi - E-mail: nampihage08@gmail.com; Phone: +91 8099616782
Ruchi Sinha - E-mail: drruchis@aiimspatna.org; Phone: +91 9162501435
Madhu Kumari - E-mail: madhukumari372@gmail.com; Phone: +91
8420374337
Tarun Kumar - E-mail: drtarunk@aiimspatna.org; Phone: +91 8860460607
Utpal Anand - E-mail: utpalanand2@gmail.com; Phone: +91 9661507725
Article Type
Research Article
Date
Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026
Abstract
Gallbladder carcinoma is an aggressive malignancy that often presents late, with limited reliable prognostic biomarkers. This cross sectional observational study of 42 histopathologically confirmed primary gallbladder cancer specimens' evaluated p53 and Ki-67 expression by immunohistochemistry. Most cases were symptomatic, predominantly proliferative and commonly involved the fundus and body; p53 mutant expression was detected in the majority of tumors and was significantly associated with elevated CEA, tumor site and lymph node involvement. Thus, Ki-67 showed a significant correlation with p53 expression, suggesting that both markers reflect tumor proliferation and aggressive biological behavior.
Keywords
Gallbladder carcinoma (GBC), carcinoembryonic antigen (CEA), p53 mutant, Ki-67
Citation
Nampi et al. Bioinformation 22(8): 5027-5033 (2026)
Edited by
Vini Mehta
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
