Title
Evaluation of quality of life among patients with chronic kidney disease on maintenance hemodialysis using the kidney disease quality of life-short form questionnaire
Authors
Pradeep Kumar Burubu1,*, Ivvala Anand Shaker2 & Hitesh Shah3
Affiliation
1Department of Biochemistry, Parul Institute of Medical Sciences and Research, Parul University, Vadodara, India; 2Department of Biochemistry, Swaminarayan Institute of Medical Sciences and Research, Kalol, India; 3Department of Biochemistry, Pramukhswami Medical College, Faculty of Medicine, Bhaikaka University, Gokalnagar, Karamsad, Gujarat, India; *Corresponding author
Pradeep Kumar Burubu - E-mail: pradeepsankalp1@gmail.com
Ivvala Anand Shaker - E-mail: ivvala.shaker@gmail.com
Hitesh Shah - E-mail: hiteshshah0708@gmail.com
Article Type
Research Article
Date
Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026
Abstract
Chronic kidney disease requiring maintenance hemodialysis is associated with substantial physical, psychological and social burden, leading to impaired quality of life. Therefore, it is of interest to assess the QoL among patients with CKD undergoing hemodialysis and evaluate its association with clinical, biochemical, oxidative stress, inflammatory and novel biomarkers. This hospital-based analytical case-control study included 450 participants. The demographic, clinical, laboratory, oxidative stress, inflammatory and molecular biomarkers were evaluated. Quality of life was assessed using the Kidney Disease Quality of Life-Short Form (KDQOL SFTM 36). Hemodialysis patients showed significantly altered laboratory parameters, increased oxidative stress and elevated inflammatory and novel biomarkers compared with controls (all p<0.001). The overall KDQOL score was 60.5 ± 18.4, with the lowest scores observed in the physical component and burden of kidney disease domains. Quality of life is impaired in patients undergoing maintenance hemodialysis and is independently influenced by age, nutritional status, inflammation, oxidative stress and dialysis related factors. Thus, early identification and targeted management of these modifiable factors may improve patient-centered outcomes.
Keywords
Chronic kidney disease (CKD), hemodialysis, quality of life (QoL), KDQOL-SFTM-36, oxidative stress
Citation
Burubu et al. Bioinformation 22(8): 5034-5041 (2026)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
