Title
Salivary biomarkers versus tissue biopsy in diagnosis of oral potentially malignant disorders
Authors
A. Sailaja Choudary1,*, N. Manjula2, M.S Abhinethra1, A.G Annaji1, S. Chitra3, T.A Deepak1 & G.D Chandan4
Affiliation
1Department of Oral Medicine and Radiology, VS Dental College and Hospital, Bangalore, Karnataka, India; 2Department of Prosthodontics, VS Dental College and Hospital, Bangalore, Karnataka, India; 3Department of Oral and Maxillofacial Pathology, VS Dental College and Hospital, Bangalore, Karnataka, India; 4Department of Pedodontics and Preventive Dentistry, VS Dental College and Hospital, Bangalore, Karnataka, India;*Corresponding author
A. Sailaja Choudary - E-mail: sailajadr@gmail.com
N. Manjula - E-mail: drmanjula87@gmail.com
M.S Abhinethra - E-mail: abhinetra@gmail.com
A.G Annaji - E-mail: dr.ag.annaji@gmail.com
S. Chitra - E-mail: docchitra22@gmail.com
T.A Deepak - E-mail: drdeepakta@gmail.com
G.D Chandan - E-mail: dentofix@gmail.com
Article Type
Research Article
Date
Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026
Abstract
An oral potentially malignant disorder (OPMDs) is a category of lesions that is at risk of developing into oral squamous cell carcinoma and early diagnosis plays a very vital role in enhancing prognosis and survival rates. The gold standard method of diagnosis is tissue biopsy, but it is invasive, technique-sensitive and inappropriate to perform in large-scale screening. Salivary biomarkers are a promising non-invasive diagnostic option due to their ease of collection, cost-effectiveness and ability to reflect real time changes in the body at the molecular level. Several biomarkers including interleukins, microRNAs, enzymes and proteins have proved to have potential diagnostic utility. Thus, data show the comparison of diagnostic effectiveness of salivary biomarkers and histopathological results obtained by using tissue biopsy in patients with OPMDs.
Keywords
Oral potentially malignant disorders (OPMDs), salivary biomarkers, tissue biopsy, oral cancer, non-invasive diagnosis, microRNA
Citation
Choudary et al. Bioinformation 22(8): 5052-5056 (2026)
Edited by
Vini Mehta
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
