Title
blaOXA and blaNDM mediated carbapenemase resistance in Acinetobacter baumannii species
Authors
Sonali Vijay Bhaisare*
Affiliation
Department of Clinical Microbiology, J. N. Medical collage Sawangi, Datta Meghe institute of Higher Education and Research ( Deemed To be University), Sawangi (Meghe), Wardha, Maharashtra, India; *Corresponding author
Sonali Vijay Bhaisare - E-mail: bhaisarevsonali@gmail.com; Phone: +91 7083849126
Article Type
Research Article
Date
Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026
Abstract
The growing rise of the occurrence of Carbapenem-Resistant Acinetobacter baumannii (CRAB) in critical care units is a disaster of the existing antimicrobial protocols, with the main cause of this problem being the dissemination of oxacillinase (OXA) and metallo-beta-lactamase (MBL) genes. In the present study, a cross-sectional molecular analysis of 215 clinical isolates was used to assess the antimicrobial susceptibility and define the genotypic presence of blaOXA-23, blaOXA-51 and blaNDM-1 by using multiplex PCR assays in a tertiary care center. The resistance to meropenem was found to be 92.5% phenotypically and intrinsic blaOXA-51 was identified in 100% of isolates with acquired blaOXA-23 (78.6) and blaNDM-1 (34.4) in 22.3%. Thus, data shows the rise of A. baumannii strains that are co-producing OXA and NDM enzymes is an indication of the transition to pan-drug resistance. Hence, combined molecular surveillance and stewardship measures are in urgent need.
Keywords
Acinetobacter baumannii, carbapenemase, blaOXA-23, blaNDM-1, antimicrobial resistance
Citation
Bhaisare, Bioinformation 22(8): 5057-5061 (2026)
Edited by
Rashmi Laddha
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
