Title
Comparative study of calcium hydroxide versus triple antibiotic paste as intracanal medicaments
Authors
Kushal U Fuladi1,*, Debadrita Ghosh2, Priyanka Kotiał, Resham Sheth4, Sagolshem Devarani Devi5 & Tarang K Mehta6
Affiliation
1Department of Conservative
Dentistry and Endodontics, Ranjeet Deshmukh Dental College and
Research Center, Nagpur, Maharashtra, India; 2Department
Of Pediatric and Preventive Dentistry, Haldia Institute Of Dental
Sciences & Research, Purba Medinipur, West Bengal, India; 3Department
of Dentistry, Dr. Sonelal Patel Autonomous State Medical College,
Pratapgarh, Uttar Pradesh, India; 4Shree Sainath Dental
Clinic, Silvassa, Dadra and Nagar Haveli, India; 5Department
of Pedodontics and Preventive Dentistry, Vyas Dental College and
Hospital, Jodhpur, Rajasthan, India; 6Department of Oral
and Maxillofacial Pathology and Oral Microbiology, K M Shah Dental
College and Hospital, Sumandeep Vidyapeeth Deemed to be University,
Vadodara, Gujarat, India; *Corresponding author
Kushal U Fuladi - E-mail: drkushfuladi@gmail.com;
Phone: +91 9421708923
Debadrita Ghosh - E-mail: debadrita.ghosh12@gmail.com
Priyanka Kotia - E-mail: p.kotia28@gmail.com
Resham Sheth - E-mail: drreshamsheth@gmail.com
Sagolshem Devarani Devi - E-mail: sagolshemdevarani94@gmail.com
Tarang K. Mehta - E-mail: tarangmehta111@gmail.com
Article Type
Research Article
Date
Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026
Abstract
Persistent microorganisms, particularly Enterococcus faecalis, may survive chemomechanical preparation and compromise root canal disinfection, necessitating effective intracanal medicaments. Therefore, it is of interest to evaluate the 100 patients with necrotic single-rooted teeth, randomly allocated to calcium hydroxide (n=50) or triple antibiotic paste (n=50), assessing postoperative pain and microbial reduction. Triple antibiotic paste produced significantly greater pain reduction at 24, 48 and 72 hours (p=0.01, 0.002 and 0.01) and greater microbial reduction (99.1% vs. 96.8%; p=0.001) than calcium hydroxide. Both medicaments were effective, but triple antibiotic paste provided superior antimicrobial activity and faster pain relief against persistent endodontic infection. Thus, data shows triple antibiotic paste as an effective intracanal medicament while emphasizing individualized selection based on clinical needs and potential risks such as tooth discoloration and antibiotic resistance.
Keywords
Calcium hydroxide; triple antibiotic paste (TAP); intracanal medicament; root canal disinfection; Enterococcus faecalis; endodontics
Citation
Fuladi et al. Bioinformation 22(8): 5096-5100 (2026)
Edited by
Vini Mehta
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
