Title
Neuroprotective effects of pyridoxine-levetiracetam on cognitive dysfunction and oxidative stress in PTZ -kindled rats
Authors
Nikhil Chahal, Heenu Dhar*, Arka Mondal, Poonam Salwan, Kaptan Singh & Shaurya Kumar
Affiliation
Department of Pharmacology, Faculty of Medicine & Health Sciences, SGT University, Gurgaon, Haryana-122505, India; *Corresponding author
Nikhil Chahal - E-mail:
nchahal5134@gmail.com; Phone: +91 8930464228
Heenu Dhar - E-mail: heenu_fmhs@sgtuniversity.org; Phone: +91
7011054541
Arka Mondal - E-mail: arka_fmhs@sgtuniversity.org;
Phone: +91 7706978429
Poonam Salwan - E-mail: poonam_FMHS@sgtuniversity.org; Phone:
+9910925873
Kaptan Singh - Email: kaptan_fmhs@sgtuniversity.org; Phone:
+9999887066
Shaurya Kumar - Email: shauryakumar1235@gmail.com; Phone: +91
7845024180
Article Type
Research Article
Date
Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026
Abstract
Pentylenetetrazole-induced kindling causes progressive seizures, behavioural impairment and oxidative stress. Therefore, it is of interest to evaluate the effect of pyridoxine combined with low-dose levetiracetam in PTZ-kindled Wistar rats. The combination of pyridoxine 200 mg/kg and levetiracetam 50 mg/kg significantly reduced seizure severity, escape latency and malondialdehyde levels compared with PTZ controls (P < 0.0001). Combination therapy significantly increased glutathione, superoxide dismutase and catalase activities and produced the lowest median modified Racine score. Pyridoxine therefore potentiated the anticonvulsant and neuroprotective effects of low-dose levetiracetam during epileptogenesis.
Keywords
Pyridoxine; levetiracetam; pentylenetetrazol (PTZ) kindling; oxidative stress; cognition; epilepsy; rats
Citation
Chahal et al. Bioinformation 22(8): 5101-5108 (2026)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
