Title

Assessment of pathological and biochemical investigations in CKD patients on hemodialysis

Authors

Pradeep Kumar Burubu¹, Ivvala Anand Shaker^2,* & Brahma Reddy Malapati³

Affiliation

¹Department of Biochemistry, Parul Institute of Medical Sciences and Research, Parul University, Vadodara, India; ²Department of Biochemistry, Swaminarayan Institute of Medical Sciences and Research, Kalol, India; ³Department of biochemistry, Prince Medical College & Hospital, Bajor, Sikar, Rajasthan, India; *Corresponding author

Email

Pradeep Kumar Burubu - E-mail: pradeepsankalp1@gmail.com

Ivvala Anand Shaker - E-mail: ivvala.shaker@gmail.com
Brahma Reddy Malapati - E-mail: brahmareddy.malapati@gmail.com

Article Type

Research Article

Date

Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026

Abstract

Chronic kidney disease (CKD) is a progressive disorder characterized by gradual loss of renal function, leading to metabolic, hematological and biochemical disturbances. Hemodialysis, a common renal replacement therapy, can influence these parameters, impacting patient outcomes. This cross-sectional study included 110 CKD patients undergoing maintenance hemodialysis and 101 age- and sex-matched healthy controls. Demographic data were collected and blood samples were analyzed for hematological indices and biochemical indices. The CKD patients had higher age and significantly elevated glycemic and renal parameters. Hematological assessment showed anemia, increased RDW, leukocytosis and altered platelet indices. Biochemical evaluation revealed hypoalbuminemia, dyslipidemia, disturbed mineral and iron metabolism and elevated CRP compared to controls (all p<0.05). The CKD and hemodialysis are associated with profound metabolic, hematological and inflammatory alterations, showing the need for comprehensive laboratory monitoring to improve clinical management.

Keywords

Chronic kidney disease (CKD), hemodialysis, CBC, protein profile, lipid profile, renal function tests, inflammation, dyslipidemia

Citation

Burubu et al. Bioinformation 22(8): 5119-5123 (2026)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.