Risk of malignancy index and its implication in clinicopathological evaluation for ovarian mass

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Title	Risk of malignancy index and its implication in clinicopathological evaluation for ovarian mass
Authors	Bharti Kumariš, Rashmi Rani Bhartiš, Pankaj Kumar Chaudhary˛, Guddi Rani Singhš,*, Namita Singhš, Sangeeta Pankajł & Neetu Sinha⁴
Affiliation	šDepartment of Pathology, Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, Bihar, India; ˛Medical Officer, Referral Hospital, Mokama, Patna, Bihar, India; łDepartment of Gynaecological Oncology (SCI), Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, Bihar, India; ⁴Department of Radiology, Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, Bihar, India; *Corresponding author
Email	Bharti Kumari - E-mail: bchoudhary1012@gmail.com Rashmi Rani Bharti - E-mail: rashmi.99.rims@gmail.com Pankaj Kumar Chaudhary - E-mail: pankajchaudhary.dr@gmail.com Guddi Rani Singh - E-mail: drgrsinghpatho@gmai.com Namita Singh - E-mail: namitasingh1312@gmail.com Sangeeta Pankaj - E-mail: drsangeetapankaj@gmail.com Neetu Sinha - E-mail: dr.neetu.sinha@gmail.com
Article Type	Research Article
Date	Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026
Abstract	Accurate pre-operative differentiation of benign, borderline and malignant ovarian masses is essential for appropriate treatment planning and patient outcomes. Therefore, it is of interest to evaluate the diagnostic performance of the risk of malignancy index in 155 ovarian mass cases over 1 year, using ultrasound findings, menopausal status and serum cancer antigen 125 levels, with histomorphological examination as the reference standard. Ovarian-adnexal reporting and data system ultrasound classification will also be assessed to improve pre-operative diagnostic accuracy. The study will determine the risk of malignancy index to stratify ovarian masses linking with histological findings. Thus, we describe a practical and economical approach to pre-operative ovarian mass stratification and decision-making.
Keywords	Risk of malignancy index (RMI), ovarian mass, cancer antigen 125 (CA-125), ovarian-adnexal reporting and data system (O-RADS), histopathology, menopausal status
Citation	Kumari et al. Bioinformation 22(8): 5154-5158 (2026)
Edited by	Vini Mehta
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.