Title
Stem cell-mediated periodontal regeneration: A mini review
Authors
Dustin De la Paz-Tamaki1,*, Karla Fernanda Valente2, Angela Alcala3, Frank Perez Cobos4, Diane Lobaina Ceballos5 & Claudia Sosa Machado6
Affiliation
1Department of Dentistry, University of Medical Sciences of Havana, Cuba, Caribbean; 2Department of Dentistry, San Martin University Foundation, Colombia, South America; 3Department of Dentistry, El Bosque University, Colombia, South America; 4Department of Dentistry, University of Medical Sciences of Matanzas, Cuba, Caribbean; 5Department of Dentistry, University of Medical Sciences of Guantanamo, Cuba, Caribbean; 6Department of Dentistry, University of Medical Sciences of Villa Clara, Cuba, Caribbean; *Corresponding author
Dustin De la Paz -Tamaki - E-mail:
delapaz9407@gmail.com
Karla Fernanda Valente - E-mail: karlafvalente@gmail.com
Angela Alcala - E-mail: angelaalcala92@gmail.com
Frank Perez Cobos - E-mail: rankcobos1997@icloud.com
Diane Lobaina Ceballos - E-mail: dmlobaina90dentist@gmail.com
Claudia Sosa Machado - E-mail: sosamachadoclaudia@yahoo.com
Article Type
Views
Date
Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026
Abstract
Restoring periodontal attachment in intrabony defects remains unpredictable with conventional therapy. Mesenchymal stem cells, including PDLSCs, DPSCs and GMSCs, aid repair through differentiation, paracrine signaling and immune regulation. Transcriptomic and single-cell RNA sequencing analyses show osteogenic and angiogenic drivers, including RUNX2, BMP2 and PDGFRA-positive lineages. Extracellular vesicle profiling and multi-omics integration, aided by machine learning, are refining biomarkers and cell-free protocols. Thus, molecular signatures with clinical outcomes through standardized pipelines points toward personalized periodontal regeneration.
Keywords
Periodontal regeneration; mesenchymal stem cells (MSCs); single-cell RNA sequencing
Citation
Shetty et al. Bioinformation 22(8): 5170-5172 (2026)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
