Title

Efficacy and safety of intranasal tapentadol versus intravenous tramadol for post-operative analgesia

Authors

Vaishali Dwivedi^1,*, Pranay Hedaoo², Abha Bardiya³, Hansraj Baghel⁴, Nidhi Pandey⁴ & Pradeep Kumar Pathak⁵

Affiliation

¹Department of Anaesthesiology, Government Medical College, Satna, Madhya Pradesh, India; ²Department of Anaesthesiology, Nandkumar Singh Chouhan Government Medical College, Khandwa, Madhya Pradesh, India; ³Department of Anaesthesiology, Government Medical College, Datia, Madhya Pradesh, India; ⁴Department of Anaesthesiology, Shyam Shah Medical College, Rewa, Madhya Pradesh, India; ⁵Department of Orthopaedics, Teerthanker Mahavir Medical College and Research Centre, Moradabad, Uttar Pradesh, India; *Corresponding Author

Email

Vaishali Dwivedi - E-mail: vaishalidwivedi345@gmail.com
Pranay Hedaoo - E-mail: pranay.hedaoo@gmail.com
Abha Bardiya - E-mail: bardiya.abha@gmail.com
Hansraj Baghel - E-mail: dr.hansrajbaghel@gmail.com
Nidhi Pandey - E- mail: nidhi1229pandey37@gmail.com
Pradeep Kumar Pathak - E-mail: dr.pathak09@gmail.com

Article Type

Research Article

Date

Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026

Abstract

Post-operative pain management is a vital aspect of perioperative management, especially in the management of pain following major surgery of the lower limb and hip. Good pain management will make the patient more comfortable, help get the patient moving early and help prevent complications. Hence, this prospective randomized study compares the efficacy and safety of intranasal tapentadol and intravenous tramadol for post-operative analgesia in 100 patients under regional anesthesia. Patients were split into two groups: one that received intranasal tapentadol and the other intravenous tramadol at a fixed time interval. The Visual Analogue Scale (VAS) was used to evaluate pain, and hemodynamic parameters, adverse effects and patient satisfaction were monitored. Thus, we compare the efficacy, safety, and patient satisfaction of IN tapentadol to IV tramadol.

Keywords

Intranasal tapentadol; intravenous tramadol; patient satisfaction; post-operative analgesia; regional anesthesia; vas score

Citation

Dwivedi et al. Bioinformation 22(8): 5336-5340 (2026)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.