Title
Post-evacuation surveillance of hydatidiform mole: A six-year experience at Bangladesh Medical University
Authors
Farzana Sharmin*, Khairun Nahar, Rownok Jahan, Arunthiya Shoma Saha, Suraiya Parvin & Sayema Tabassum
Affiliation
Department of Gynecological Oncology, Bangladesh Medical University, Dhaka, Bangladesh; *Corresponding author
Farzana Sharmin - E-mail: farzanasharmin@bsmmu.edu.bd
Khairun Nahar - E-mail: khairunnaharshaon@bsmmu.edu.bd
Rownok Jahan - E-mail: drrjshamoli@gmail.com
Arunthiya Shoma Saha - E-mail: arunthiyashoma@gmail.com
Suraiya Parvin - E-mail: suraiya.mmc93@gmail.com
Sayema Tabassum- E-mail: tabassumsayema881@gmail.com
Article Type
Research Article
Date
Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026
Abstract
Hydatidiform mole is the most common form of gestational trophoblastic disease and requires careful post-evacuation surveillance to enable early detection of persistent gestational trophoblastic neoplasia (PGTN). This retrospective observational study included 330 patients with histopathologically confirmed hydatidiform mole who underwent uterine evacuation, with demographic, clinical, pathological and serial serum β-human chorionic gonadotropin (β-hCG) follow-up data retrieved from hospital records. Most patients were aged 21–30 years (51.8%), presented with abnormal vaginal bleeding (83.6%), had pre-evacuation β-hCG levels ≥100,000 mIU/mL (66.1%) and underwent suction evacuation (71.5%). Serum β-hCG normalised in 289 (87.6%) patients, whereas 41 (12.4%) developed PGTN, of whom 70.7% were diagnosed within 6 months and 80.5% responded to single-agent chemotherapy; higher pre-evacuation β-hCG levels were associated with persistent disease. Thus, serial β-hCG surveillance following evacuation remains an effective strategy for early detection of PGTN and timely initiation of chemotherapy, leading to favourable clinical outcomes.
Keywords
Hydatidiform mole; gestational trophoblastic neoplasia (GTN); β-human chorionic gonadotropin (β-hCG); post-evacuation surveillance; chemotherapy; molar pregnancy
Citation
Sharmin et al. Bioinformation 22(8): 5411-5416 (2026)
Edited by
Hiroj Bagde
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
