Title
Adjunctive aloe vera gel in diabetic and non-diabetic periodontitis: A split-mouth trial
Authors
Shikha Verma, Shruti Gupta*, Rohit Ranjan, Utkarsh Singh, Manas Srivastava & Rajani Umar
Affiliation
Department of Periodontology, Rama Dental College Hospital & Research Centre, Kanpur, Uttar Pradesh, India; *Corresponding author
Shikha Verma - E-mail:
vermashikha544@gmail.com
Shruti Gupta - E-mail: shrutz26@gmail.com
Rohit Ranjan - E-mail: drrohitperio2611@gmail.com; Phone: 8987249650
Utkarsh Singh - E-mail: drutkarshsinghsurgeon@gmail.com
Manas Srivastava - E-mail: drmanassrivastava@gmail.com
Rajani Umar - E-mail: dr.rajaniumar@gmail.com
Article Type
Research Article
Date
Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026
Abstract
Periodontitis in patients with diabetes is clinically challenging because periodontal inflammation, microbial persistence and delayed wound healing may reduce the predictability of non-surgical periodontal therapy. Therefore, it is of interest to evaluate whether subgingival Aloe vera gel used as a local drug delivery agent could improve periodontal outcomes when added to scaling and root planing in diabetic and non-diabetic adults with Stage I or Stage II periodontitis. Forty participants, including 20 well-controlled type 2 diabetic and 20 non-diabetic patients, contributed 80 periodontal sites allocated to scaling and root planing plus Aloe vera gel or scaling and root planing alone; plaque index, gingival index, probing pocket depth and clinical attachment level were recorded at baseline, 30 days and 60 days. Both treatment modalities produced significant improvement over time, but adjunctive Aloe vera showed greater 60-day reductions in gingival index, probing pocket depth and clinical attachment level, particularly among diabetic patients, where clinical attachment level improved by 1.07 mm versus 0.78 mm with scaling and root planing alone (p = 0.018). Thus, aloe vera gel is a safe, economical and biologically acceptable adjunct to non-surgical periodontal therapy, with clinically relevant benefits in inflammatory control and attachment gain, especially in diabetic and Stage II periodontitis sites.
Keywords
Aloe vera gel, periodontitis, diabetes mellitus (DM), scaling and root planing (SRP), local drug delivery (LLD), clinical attachment level (CAL)
Citation
Verma et al. Bioinformation 22(8): 5486-5491 (2026)
Edited by
Hiroj Bagde
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
