Title

Impact of non-surgical periodontal therapy on systemic inflammatory biomarkers in patients with metabolic syndrome: A randomized controlled trial

Authors

Ravindranath Dhulipalla¹,*, Krishna Rao Kilaru², Lalitha Chintala³, Sai Archita Tummala⁴, Bhavyasri Gaddam⁵ & Ramanarayana Boyapati⁶

Affiliation

¹Department of Periodontology, Sibar Institute of Dental Sciences, Takkellapadu, Guntur andhra Pradesh, India; ²Department of Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States of America; ³Department of Oral Medicine and Radiology, Malla Reddy Institute of Dental Sciences, Malla Reddy Vishwavidyapeet (Deemed to be University), Suraram, Hyderabad, Telangana, India; ⁴Department of Dentistry , EHR and Claims Analytics, Flair Dental, McKinney, Texas 75070, United States of America; ⁵Department of Oral Diagnostic Sciences & Research, School of Dentistry, MeharryMedical College, Nashville, Tennessee 37208, United States of America; ⁶Department of Periodontology, Sibar Institute of Dental Sciences, Takkellapadu, Guntur andhra Pradesh, India; *Corresponding author

Email

Ravindranath Dhulipalla - E-mail: ravident69@gmail.com
Krishna Rao Kilaru - E-mail: kkr167@pitt.edu
Lalitha Chintala - E-mail: lalitha.chintala@mrvv.edu.in
Sai Archita Tummala - E-mail: drarchitatummala3@gmail.com
Bhavyasri Gaddam - E-mail: Bgadd335@mmc.edu
Ramanarayana Boyapati - E-mail: dr.ramanarayana@gmail.com

Article Type

Research Article

Date

Received August 1, 2026; Revised August 31, 2026; Accepted August 31, 2026, Published August 31, 2026

Abstract

Metabolic syndrome is associated with chronic low-grade inflammation and periodontal inflammation may add to this systemic inflammatory burden. Therefore, it is of interest to evaluate the effect of non-surgical periodontal therapy on periodontal parameters and systemic biomarkers among 80 patients with metabolic syndrome and Stage II/III periodontitis allocated to immediate therapy or delayed therapy control. At 3 months, the therapy group showed significantly greater reductions in probing pocket depth, clinical attachment loss, periodontal inflamed surface area, high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-alpha and HbA1c than the control group. High-sensitivity C-reactive protein decreased from 4.8 ± 1.9 to 3.1 ± 1.4 mg/L in the therapy group compared with 4.7 ± 1.8 to 4.4 ± 1.7 mg/L in controls (between-group p<0.001). Thus, non-surgical periodontal therapies help reduce systemic inflammatory load and modestly improve glycemic status in metabolic syndrome, supporting periodontal care as part of integrated cardiometabolic risk management.

Keywords

Periodontitis, metabolic syndrome, C-reactive protein (CRP), interleukin-6, tumor necrosis factor-alpha, HbA1c, randomized controlled trial (RCT)

Citation

Dhulipalla et al. Bioinformation 22(8): 5492-5496 (2026)

Edited by

Hiroj Bagde

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.