Title

Target-controlled propofol infusion versus single bolus propofol for I-gel insertion: A prospective randomized study in India

Authors

Yalamanchali L. Sindhura¹, Ishrat Yousuf², Bhavana Pinnaka³, Poonam Rani⁴ & Shiva Meesala⁵,*

Affiliation

¹Department of Anesthesia, Cloud nine Hospital, Hitech City, Hyderabad, Telangana, India; ²Department of Neuroanaesthesia, Sher E-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India; ³Department of Critical Care Medicine, KIMS ICON Hospitals, Visakhapatnam Andhra Pradesh, India; ⁴Department of Anaesthesia, Aadesh Medical College and Hospital, Mohri, Haryana, India; ⁵Department of Critical Care Medicine, Abhaya Hospitals, Bobbili, Visakhapatnam Andhra Pradesh, India; *Corresponding author

Email

Yalamanchali L. Sindhura - E-mail: sindhuraones@gmail.com
Ishrat Yousuf - E-mail: eshratusuf90@gmail.com
Bhavana Pinnaka - E-mail: bhavanachowdary88@gmail.com
Poonam Rani - E-mail: prathore646@gmail.com
Shiva Meesala - E-mail: mbsivakumar86@gmail.com

Article Type

Research Article

Date

Received September 1, 2026; Revised September 30, 2026; Accepted September 30, 2026, Published September 30, 2026

Abstract

Propofol TCI delivers drug to a set effect-site concentration, unlike bolus dosing, which can cause cardiovascular and respiratory depression. Therefore, it is of interest to compare the propofol TCI (Schnider model, 6 µg/mL, n=60) with a 2.5 mg/kg bolus (n=60) for I-gel insertion in 120 ASA I–II patients. TCI gave better jaw relaxation (83% vs. 58%; p=0.001) and insertion quality (80% vs. 55%; p=0.003). TCI also used less propofol (116 vs. 157 mg; p<0.001) and preserved hemodynamics better, with no ephedrine rescue versus 15% in the bolus group. Thus, TCI offers superior insertion conditions and hemodynamic stability at the cost of longer induction (124 vs. 54 sec).

Keywords

Target controlled infusion, propofol, I-gel, supraglottic airway, Schnider model, hemodynamic stability, induction of anesthesia

Citation

Sindhura et al. Bioinformation 22(9): 5701-5705 (2026)

Edited by

Ruby Singh

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.