Title

Clinical-serological clues to Aspergillus sensitization in chronic obstructive pulmonary disease

Authors

Prerna Aggarwal¹, Suchira Chillana², Kapil AM Chilana³ & Ruchika Gupta⁴,*

Affiliation

¹Department of Microbiology, Kalpana Chawla Government Medical College, Karnal, Haryana, India; ²Department of Microbiology, Dr. S.S. Tantia Medical College & Research Centre, Sri Ganganagar, Rajasthan, India; ³Department of Respiratory Medicine, Kalpana Chawla Government Medical College, Karnal, Haryana, India; ⁴Department of Cytopathology, ICMR-National Institute of Cancer Prevention and Academy of Scientific and Innovative Research, Uttar Pradesh, India; *Corresponding author

Email

Prerna Aggarwal - E-mail: prernaaggarwal70@gmail.com
Suchira Chillana - E-mail: dr.suchira@gmail.com
Kapil Chillana - E-mail: drkapchillu@gmail.com
Ruchika Gupta - E-mail: uchika.aiims@gmail.com

Article Type

Research Article

Date

Received September 1, 2026; Revised September 30, 2026; Accepted September 30, 2026, Published September 30, 2026

Abstract

Chronic obstructive pulmonary disease (COPD) accounts for 35%-55% of the groups manifesting Aspergillus sensitization and is considered to be highly associated with severe symptoms. Therefore, it is of interest to evaluate the prevalence of Aspergillus sensitization in (COPD) and correlate with seasonal variation and respiratory symptoms. Total IgE and Aspergillus specific IgE were measured using ELISA with follow-up of patients during seasonal change. Aspergillus sensitization was found in one-third of the patients with COPD with fungal hyphae in sputum samples in 33% samples at enrolment and 40% samples at follow-up. This phenomenon should be considered in COPD patients, especially during exacerbations or emergency admissions.

Keywords

Chronic obstructive pulmonary disease (COPD), Aspergillus sensitization, total IgE, Aspergillus specific IgE

Citation

Aggarwal et al. Bioinformation 22(9): 5706-5709 (2026)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.