Title
Evaluating drug release potential of Solanum nigrum local drug delivery chip: An in vitro study
Authors
S. Sneha, Abirami Thanigaimalai*, Bhuvaneswari Birla Bose, Parthiban Sakethraman, T. Parthasarathi & C. Sri Sanjhanaa
Affiliation
Department of Periodontology, Tagore Dental College and Hospital, Dr. MGR Medical University, Rathinamangalam, Chennai, Tamil Nadu India; *Corresponding author
S. Sneha - E-mail: snehasubramanian25@gmail.com
Abirami Thanigaimalai - E-mail: abitm.ds@gmail.com
Bhuvaneswari Birla Bose - E-mail: drbhuvanabirla@tagoredch.in
Parthiban Sakethraman - E-mail: partthiban@gmail.com
T. Parthasarathi - E-mail: tparthasarathy@tagoredch.in
C. Sri Sanjhanaa - E-mail: sanjanachandran96@gmail.com
Article Type
Research Article
Date
Received September 1, 2026; Revised September 30, 2026; Accepted September 30, 2026, Published September 30, 2026
Abstract
Solanum nigrum extract was added to hydroxypropylcellulose, polyethylene glycol and polyvinyl pyrrolidine and centrifuged at 1000 rpm for 45 mins for infusion. A simulation of a continuous flow chamber was created to evaluate the in vitro drug release potential of the Solanum nigrum chip at three different concentrations of Solanum nigrum, i.e., 50, 100 and 150 microgram / ml. The drug release profile of Solanum nigrum chip over a 15-days period for three different initial concentrations (50 µg/ml, 100 µg/ml and 150 µg/ml) showed gradual decrease in the drug concentration over time, which is typical of controlled release formulations. Thus, data shows that Solanum nigrum chip can effectively be used as a controlled release local drug delivery agent in the management of periodontitis.
Keywords
Herbal medicine, solanum nigrum, anti-infective, periodontitis
Citation
Thanigaimalai et al. Bioinformation 22(9): 5724-5724 (2026)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
