Title
Comparison of D-dimer values among COVID-19 patients with and without type 2 diabetes mellitus
Authors
Numan A. Mandaty1, Surumi Azees1,* & M. Dhanuthra2
Affiliation
1Department of General Medicine, Amrita Institute of Medical Sciences & Research Center, Amrita Vishwa Vidyapeetha, Kochi, Kerala, India; 2Department of General Medicine, KIMS Avitis Hospital, Nenmara, Palakkad, Kerala, India; *Corresponding author
Numan A. Mandaty - E-mail: numanam24@gmail.com
Surumi Azees - E-mail: 1991surumiazees@gmail.com
M. Dhanuthra- E-mail: dhanuthra@gmail.com
Article Type
Research Article
Date
Received September 1, 2026; Revised September 30, 2026; Accepted September 30, 2026, Published September 30, 2026
Abstract
Individuals with Type 2 Diabetes Mellitus (T2DM) especially those with vascular complications exhibit elevated D-dimer levels. Therefore, it is of interest to evaluate the D-dimer concentrations in subjects with COVID-19, with and without Type 2 Diabetes Mellitus (T2DM). The mean D-dimer concentration was significantly higher among those with T2DM than those without T2DM (228.45 vs 112.74 ng/mL) (p=0.05). The D-dimer level was found to be abnormal in 52.2 % of diabetic patients and it was 47.8 % in non-diabetics, making it clinically significant. The mean D-dimer levels with respect to diabetes control and other inflammatory biochemical parameters, such as CRP, Ferritin and LDH, were higher in patients with diabetes than in non-diabetics. These outcomes indicate the concept that the presence of diabetes along with COVID-19 could further enhance the hypercoagulable condition induced by SARS-CoV-2 infection, thus exhibiting a higher likelihood of thrombotic complications and worse clinical outcomes.
Keywords
Chest X-ray, COVID-19, D-dimer, HbA1c, Type 2 diabetes mellitus (T2DM)
Citation
Mandaty et al. Bioinformation 22(9): 5760-5765 (2026)
Edited by
Vini Mehta
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
